Posted by admin on Jun 1, 2014 in |
Stem cell biology, many signals regulated stem cells and organ development. Wnt factors play a crucial role in stem cells development and induced signaling pathway in stem cells. Wnt signals classified as a canonical and non-canonical pathway. Wnt factors regulated both pathways for stem cells self-renewal, proliferation, and differentiation. Wnt canonical pathway induced by Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt10a and Wnt10b. Wnt non-canonical pathway regulated by Wnt factors such as Wnt1, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, Wnt9a, Wnt9b, Wnt10a, Wnt10b, Wnt11, and Wnt16. These all factors have a specialized role in stem cells and development. These factors also regulated wound healing mechanism and variety of organ regeneration. Finally, abnormality or aberrant expression of Wnt signals regulated a variety of...
Read More
Posted by admin on Jun 1, 2014 in |
Diabetes mellitus (DM), both insulin-dependent DM (IDDM) and non-insulin dependent DM (NIDDM) is a common and serious metabolic disorder throughout the world. Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Among many medications and other alternative medicines, several herbs have been known to cure and control diabetes; additionally, they have no side effects. The present paper is an attempt to list the plants with anti-diabetic and related beneficial effects originating from different parts of the world. History showed that medicinal plants had been used in traditional healing around the world for a long time to treat diabetes; this is because such herbal plants have hypoglycemic properties and other beneficial properties, as reported in scientific literature. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat diabetes mellitus, describes that the anti-diabetic activity of medicinal plants is due to the presence of phenolic compounds, flavonoids, terpenoids, coumarins and other constituents which...
Read More
Posted by admin on May 1, 2014 in |
High blood pressure is well-established as a leading cause of stroke, ischemic heart disease, and cardiovascular disease. Globally cardiovascular disease accounts for approximately 17 million deaths a year, nearly one third of the total. A number of pharmaceutical agents are available for initial treatment of high BP. These include older molecules such as diuretics and beta-blocking agents, and newer molecules such as dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and direct acting vasodilators. Comprehensive hypertension management focuses on reducing overall cardiovascular risk and should be the preferred approach for initial management of hypertension. Nitric oxide is a gaseous signaling molecule that regulates various physiological and pathophysiological responses in the human body. Nitric oxide is a gaseous lipophilic free radical which reacts with various molecules to cause pleiotropic effects and it is generated by three distinct isoforms of nitric oxide synthase. The physiologic effects include circulation and blood pressure, platelet function, host defense, and neurotransmission in central nervous system and in peripheral nerves. The etiology of the...
Read More
Posted by admin on May 1, 2014 in |
Bauhinia Variegata Linn. is a widely used medicinal plant distributed in the tropical regions throughout the world. Its various part i.e. flowers, flower buds, stem, roots, stem bark, seeds, leaves have been used since ancient times for the treatment of a large range of diseases such as dysentery, diarrhoea, haemorrhoids, piles, oedema, laxative, anthelmintic, astringent, antileprotic, wound healing, antigoitrogenic, antitumor, antidote for snake poisoning, dyspepsia, carminative etc. The plant contains several flavonoids, steroids, glycosides, reducing sugars as active constituents that bring about its biological effects. Preclinical (in-vivo and in-vitro) investigations have demonstrated pharmacological activities such as antioxidant, hypolipidemic, immunomodulatory, anti-inflammatory, antimicrobial, insecticidal, antibacterial, antidiabetic, antiulcer, hepatoprotective, anti-arthritic, anti-mutagenic, cytotoxic, trypsin inhibitor, anti-goitrogenic. This review represents a detailed survey of literature on plant profile, phytochemistry, and pharmacological activities of Bauhinia variegate...
Read More
Posted by admin on Apr 1, 2014 in |
Both physicians and dermatology patients are searching for long term skin care solutions to address problems presented by skin hyperpigmentation. Traditional depigmenting agents such as hydroquinone, corticosteroids, kojic acid, although highly effective, can raise several safety concerns (for example, ochronosis, atrophy, carcinogenesis, and other local and systemic side effects) with long term exposure. An understanding of the benefits of natural and botanical extracts provides opportunities to develop new products to address pigmentation problems. This study presents an overview of trends in the application of plant extracts for the treatments of hyperpigmentation disorders. It highlights some of the potent natural products, their specific components, mode of action and optimum...
Read More