DIOSPYROS MELANOXYLON ROXB IN CANCER PREVENTION: PHARMACOLOGICAL SCREENING, PHARMACOKINETICS AND CLINICAL STUDIES
AbstractPlants contain a galaxy of phytoconstituents which accounts for their remedial worth. This plant has been used expansively for its medicinal value all over the world. Different plant parts have been used for its different pharmacological screening, including cancer therapy and leaves can be wrapped to create the “beedi” filled with tobacco which has outsold conventional cigarettes in India. Extraction of plant material with organic solvent and elucidation of pure compounds using a different technique with the different solvent system are an extremely imperative limitation. Elucidation of pentacyclic triterpenoid, ursolic acid from D. melanoxylon and molecular mechanisms has vast chances for the development of enhanced therapy for different diseases, including cancer, and clinical studies. Our extensive intention of this study is to give a general delineate on the thyme D. melanoxylon and its cancer prevention potential, diverse pharmacological action, ethnomedicinal uses, and chemical compounds. We also focus the extraction methodology, elucidation, pharmacokinetic and various clinical trials of ursolic acid chiefly obtained from D. melanoxylon.
Article Information
2
217-223
518
918
English
IJP
M. H. A. Rashid *, V. Mandal, S. C. Mandal and R. A. Thandavarayan
Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
mdharunalrashid15@gmail.com
31 March 2017
22 May 2017
30 May 2017
10.13040/IJPSR.0975-8232.IJP.4(7).217-23
01 July 2017