Posted by admin on Jun 30, 2026 in |
Clerodendrum inerme (L.) [syn. Volkameria inermis] is a traditional medicinal plant used to treat against viral, neurological, metabolic, and inflammatory illnesses. It had not had a comprehensive synthesis of its traditional knowledge and up to date molecular pharmacology even after a number of experimental research. Concentrating on mechanistic data, the present research tries critically to evaluate and revise the pharmacognostic characters, phytochemical structure, and pharmacological action of C. inerme. Relevant materials in the electronic databases, including PUBMED, SCOPUS, and GOOGLE SCHOLAR were carefully searched to obtain literature published until 2025. According to the information now available, the plant is abundant in bioactive secondary metabolites that are linked to a variety of biological activities, including flavonoids, diterpenoids, phenolics, and iridoid glycosides. Through the regulation of oxidative stress, inflammatory signalling pathways, neurotransmitter systems, and enzyme activity, pharmacological investigations show notable anti-inflammatory, antioxidant, neuroprotective, antibacterial, antidiabetic, and hepatoprotective effects. However, translational interpretation is constrained by inconsistent experimental design, a lack of standardised extracts, and a paucity of toxicological and clinical data. The...
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Posted by admin on Jun 30, 2026 in |
Obesity and overweight is excessive or abnormal accumulation of fat in body that presents a risk to health. Overweight and obesity have reached epidemic proportions, with over four million individuals dying every year as a result of their condition. Different approaches comprising biological sources, different drug therapy, have been used in obesity treatment; though, these unoriginal selections linger unproductive and carry risks of adverse drug reaction. Hence, treatment with high efficacy and specificity is the need of the hour. Novel drug delivery system use herbal medicines and chemical entities to develop healing efficacy, target oriented through herbal approach for equilibrium, controlled release of antiobesity agents. In this review, we provide insights into current treatments for obesity with a focus on recent developments of herbal polymeric carriers for improved antiobesity drug...
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Posted by admin on Jun 30, 2026 in |
Diabetes mellitus is a long -term condition that affects how the body processes glucose, leading to constantly high blood sugar levels due to issues with insulin production and after effects. The widespread incident of diabetes is increasing, and it is associated with owing to sedentary lifestyles, obesity, unhealthy dietary habits, genetic predisposition, and environmental factors. Chronic hyperglycemia contributes to oxidative stress, inflammation, mitochondrial dysfunction, and dysregulation of signaling pathways such as NF-κB, PI3K/Akt, AMPK, MAPK, leading to microvascular and macrovascular complications. Conventional diabetes treatment mainly manages sugar level that might lead to long term challenges such as low blood sugar, stomach problems, harm to organs, weight increase, resistance to drugs, and restricted capability to avoid diabetes-related complications. Plant-based treatments a supportive and targeted approach for managing diabetes. With strong abilities to lower blood sugar, reduce oxidative stress, fight inflammation, and protecting insulin-producing cells and signaling, expand sugar usage by cells, reducing harmful free radicals, and confining inflammation-related substances. Current development in nano-based formulations and technique for delivering plant chemicals...
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Posted by admin on Jun 30, 2026 in |
Swietenia macrophylla King, widely recognized as big-leaf mahogany or sky fruit, is a highly prized tropical hardwood species belonging to the Meliaceae family traditionally used for managing diabetes, hypertension, inflammation, and various other ailments. Despite growing research interest, existing studies remain fragmented, largely limited to in vitro and acute animal models, with significant variability in extract preparation and scarce standardized clinical data. This review systematically compiles, organizes, and critically analyzes the botanical description, taxonomic classification, ethnomedicinal uses, major bioactive compounds, broad spectrum of pharmacological activities, toxicity and safety analysis of Swietenia macrophylla. The plant is notably high in limonoids like swietenine, swietenolide, and various derivatives, which contribute to its significant pharmacological potential, including antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, anti-aging, wound healing, and other effects. Pharmacological studies have demonstrated significant bioactivities through multiple mechanisms, notably modulation of Nrf2, NLRP3 inflammasome, PPARγ activation and related pathways. The present work offers a consolidated and up-to-date framework that addresses research gaps, variability in extract efficacy, and the need for further clinical validation, thereby...
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Posted by admin on May 31, 2026 in |
Lung cancer, which is primarily caused by smoking tobacco products, environmental pollutants, and genetic predispositions, continues to be ranked among the biggest contributors of cancer-related death worldwide. Numerous sophisticated cancer treatment methods are inefficient because of metastatic spread and susceptibility to traditional anti-cancer medications. Natural therapeutic compounds developed from plants are presently of considerable curiosity because of their excellent absorption and lack of side effects. Relevant instances involve ginsenosides (from ginseng), curcumin (from Curcuma longa), resveratrol (from grapes), and epigallocatechin gallate (from green tea). These compounds all alter important molecular pathways linked to the growth of lung cancer including NF-κB, STAT3, MAPK, and PI3K/Akt signalling. This article highlights the molecular understandings, experimental evidence, and fresh clinical data that support the utilization of natural products effective adjuvant and chemo preventive therapy for lung...
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