Posted by admin on Aug 31, 2025 in |
This literature review comprehensively explores the scientific foundation for establishing cell suspension cultures of Ixora coccinea and investigating its biochemical compounds. Ixora coccinea, a species native to India and utilized extensively in traditional Ayurvedic and folk medicine, is recognized for its diverse pharmacological activities attributed to a rich array of secondary metabolites. The plant’s classification as a threatened species underscores the imperative for sustainable production methods, which plant cell suspension culture effectively addresses. This review details the botanical and phytochemical profile of I. coccinea, elucidates the principles and methodologies of plant cell suspension culture, examines the current status of Ixora in-vitro studies and relevant examples from the Rubiaceae family, and outlines qualitative and quantitative analytical techniques for biochemical compound identification. While offering significant advantages such as scalability and controlled production, plant cell culture presents challenges including genetic instability and contamination. The successful implementation of this project holds substantial promise for the sustainable bioproduction of valuable pharmaceutical compounds, contributing to both natural product research and biodiversity...
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Posted by admin on Aug 31, 2025 in |
Spirulina is a filamentous, spiral-shaped blue-green algae that contains a wide variety of bioactive compounds, making it a valuable nutraceutical. It boasts a unique combination of approximately seventy biologically active compounds, which enhances its therapeutic significance. Its potential role in combating carcinogenesis can be attributed to its antioxidant and anti-inflammatory properties, recognitions to components such as β-Carotene, C-Phycocyanin, Calcium Spirulan, and Linoleic and Linolenic acids. Investigation has shown that Spirulina extracts can enhance endonuclease activity, promote DNA repair, and induce apoptosis in cells. Some studies have also reported effects such as myelosuppression and improved immune function. Commercially available Spirulina is often used as an adjunct to chemotherapy. However, the evidence supporting its effectiveness in cancer treatment is quite limited, particularly in terms of clinical trials. This current work aims to consolidate contemporary data and create a systematic review of the...
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Posted by admin on Aug 31, 2025 in |
Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine disorder that affects a significant percentage of women of reproductive age, with substantial implications for metabolic, reproductive, and psychological health. This review aims to provide a comprehensive overview of current research on the pathophysiology, diagnosis, and treatment approaches for PCOS. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, yet its presentation varies greatly among individuals, complicating diagnosis and management. Key findings from recent studies suggest that genetic predispositions, lifestyle factors, and environmental influences contribute to the heterogeneity of PCOS. Additionally, the review explores the role of insulin resistance and chronic low-grade inflammation in exacerbating the condition. Treatment strategies include lifestyle modifications, pharmacotherapy, and hormonal regulation, tailored to manage symptoms and improve overall quality of life. This article synthesizes current evidence to underscore the importance of an individualized, multidisciplinary approach to PCOS management and identifies gaps in research, emphasizing the need for further investigation into the underlying mechanisms and long-term treatment...
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Posted by admin on Jun 30, 2025 in |
Diabetes mellitus is a globally prevalent chronic metabolic disorder characterized by hyperglycemia due to insufficient insulin production or impaired insulin utilization. It is associated with various acute and chronic complications, including neuropathy, nephropathy, retinopathy, and cardiovascular diseases. With rising incidence rates, especially in urban regions of developing countries like India, diabetes poses a major public health challenge. While conventional treatments involve insulin therapy and oral hypoglycemics, herbal medicine offers a promising complementary approach. This study reviews the antidiabetic potential of several medicinal plants, such as Momordica charantia, Aloe barbadensis, Catharanthus roseus, Glycyrrhiza glabra, Syzygium cumini, Curcuma longa, Stevia rebaudiana, Senna auriculata, Cinnamomum cassia, and Taraxacum officinale. Each plant is explored for its phytoconstituents, such as alkaloids, flavonoids, glycosides, and terpenoids, which exhibit hypoglycemic, antioxidant, anti-inflammatory, and insulin-mimetic properties. Experimental evidence from in-vivo and in-vitro studies supports their efficacy in managing blood glucose levels, improving insulin sensitivity, and protecting pancreatic β-cells. This compilation emphasizes the therapeutic potential of herbal remedies as safe and cost-effective adjuncts in diabetes management and encourages...
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Posted by admin on Jun 30, 2025 in |
Hyperlipidemia is a significant contributor to the global burden of cardiovascular diseases, such as coronary heart disease and stroke. Characterized by elevated plasma lipids, including cholesterol, triglycerides, and lipoproteins, hyperlipidemia is a prevalent health issue with increasing incidence in both developed and developing countries. According to the World Health Organization (WHO), raised cholesterol levels are linked to 4.5% of global deaths and account for 29.7 million disability-adjusted life years (DALYs) annually. The Fredrickson classification system, endorsed by WHO, categorizes hyperlipidemia into six types based on lipoprotein abnormalities, providing a foundation for understanding its diverse etiologies and clinical implications. Experimental induction of hyperlipidemia is pivotal for studying its pathophysiology and testing potential therapeutic interventions. Various screening methods have been developed, including the use of pharmacological agents, dietary modifications, and genetic models. This review discusses the epidemiology, classification, and methodologies used to induce hyperlipidemia in experimental settings, highlighting their relevance in advancing our understanding and management of this critical public health...
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