Posted by admin on Sep 2, 2015 in |
Objective: a Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhizic acid (GA) is chemically pentacyclic triterpenoid which possesses powerful anti-inflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepared using heat seal technique using 23 factorial design allowing for independent variables like penetration enhancers, formulation matrix and rate controlling membranes. The GA patches were evaluated for in-vitro and ex-vivo drug permeation through cellophane membrane and rat skin respectively. The biological evaluation regarding skin irritation study and the anti-inflammatory effect of GA patches on rat paw edema were tested and compared with standard Aceclofenac patch. Result: The reservoir-type patch of F4 formulation, containing 5% menthol as a permeation enhancer, 42% ethanol, 2% carpool 934 gel bases (50 g) with 0.5% piperine provided an improved sustained release of phytopharmaceuticals through transdermal administration. The anti-inflammatory action F4 formulation showed no skin irritation with significant inhibition of rat paw...
Read More
Posted by admin on Sep 2, 2015 in |
The present study was to evaluate the physicochemical changes that take place in vasarishta during the manufacturing of the arishtams (hydro-alcohol class of drug of Ayurveda). The manufacturing process of the Arishtams usually takes 21 -30 days. The time period of the entire study was 21 days. Batch fermentation was done for a period of 14 days after which the fermentation process was inhibited using methods recommended in Ayurvedic literature and as per the company’s standard operating procedure. The arishtam was analysed for its physicochemical parameters periodically at an interval of 24 h. The parameters chosen for the physicochemical characterisation of the fermentation process were pH, Temperature, Specific gravity, Brix value, Sugar content, Alcohol content, Free amino acid content and Tannin content. The pH was found to vary between 4.30 and 5.57. The temperature was found to vary randomly between 25 ºC and 29 ºC throughout the period. The specific gravity was found to decrease drastically up to the 14th day followed by a gradual increase up to the...
Read More
Posted by admin on Aug 13, 2015 in |
Introduction: The phytochemicals in medicinal plants are defined as bioactive non-nutrient plant compounds in fruits, vegetables, and grains that have been linked to reducing the risk of major chronic diseases. The medicinal plant is promising to have such have effective medicinal property due to the presence of phytochemical compounds like alkaloids, tannins, flavonoids, and phenolic compounds. The present study aimed to find the phytochemicals present in hexane and ethyl acetate extracts of Justicia tranqubarieansis and Bauhinia racemosa and also find out the antioxidant property of these plant extracts. Methods: Chemical methods identified phytochemicals present in the hexane and ethyl acetate extract of Justicia tranqubarieansis and Bauhinia racemosa. The antioxidant property was done by DPPH free radical scavenging method. Results: In Justicia tranqubarieansis, hexane extract showed positive for flavonoids, alkaloids, and coumarins. Ethyl acetate extract showed positive for flavonoids, alkaloids, cardiac glycosides, terpenoids, coumarins, and steroids. The hexane extract of Bauhinia racemosa showed positive for flavonoids, alkaloids, quinines, cardiac glycosides, terpenoids, and coumarins. Ethyl acetate extract showed positive for flavonoids,...
Read More
Posted by admin on Aug 13, 2015 in |
Antioxidants play an essential role in the inhibition of the oxidative damage of the biomolecules. Flavonoids are known as potent antioxidants and are present in abundance in many of the fruits and vegetables besides being present in a large number of medicinal botanicals. A quantitative analysis of the antioxidant activity of quercetin, luteolin, kaempherol and taxifolin belonging to the flavonoid class of compounds, has been obtained by the determination of the structures, energetics and global reactivity descriptors in both neutral and charged states using Density Functional Theory. A comparison of the antioxidant property of these flavonoids, with those of the vitamins viz. vitamin A and vitamin E molecules, reveals that these flavonoid molecules are better candidates for electronic charge transfer to the ROS and hence possesses greater antioxidant activity. To probe the preferred site of reactivity, the Fukui function; fk- was also evaluated for each of these antioxidant molecules. The trends observed in various reactivity descriptors along with Fukui indices indicates that the substitution of B-ring and the C2-C3...
Read More
Posted by admin on Aug 13, 2015 in |
The purpose of this research work was to develop and evaluate matrix-type transdermal patches of Ketoprofen. Employing different ratios of hydrophilic and hydrophobic polymers by a solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by Infrared Spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Seven formulations (Consisting of hydroxypropyl methylcellulose E5 and ethylcellulose in the ratios of10:0, 0:10, 1:9, 2:8, 3:7, 4:6, 5:5 (F1, F2, F3, F4, F5, F6, F7) were prepared. All formulations carried dimethyl sulfoxide as a penetration enhancer and dibutyl phthalate as a plasticizer in chloroform and methanol (1:1) as the solvent system. The prepared TDDS were evaluated for in-vitro release, moisture absorption, moisture loss, and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. Patch coded as F1 (HPMC alone) showed maximum release of 95.526 ± 0.982% in 8 h, whereas F2 (EC alone) showed maximum release of 67.078 ± 1.875% in 24 h and combination of polymers F7 (5:5)...
Read More