Posted by admin on Jan 30, 2016 in |
Aim of the present study is to analyze Mūcāmparap paṛṛu, a poly herbomineral Siddha formulation for physicochemical parameters, TLC photo documentation, and HPTLC fingerprint profile studies. The physicochemical parameters such as ash contents, solubility in water and ethanol, pH, loss on drying and successive extraction with hexane, chloroform, and ethanol were carried out. Hexane, chloroform, and ethanol extracts were subjected to TLC photo documentation, HPTLC analysis. HPTLC fingerprint profile under UV 254 nm, hexane extract showed 13 peaks, chloroform showed 9 peaks and ethanol showed 10 peaks; under UV 366 nm, hexane showed 11 peaks, chloroform showed 15 peaks and ethanol showed 12 peaks; after derivatization with vanillin-sulphuric acid all the extracts showed 11 peaks. The results obtained in the study are specific and could be used as a reference in the quality control of the...
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Posted by admin on Jan 30, 2016 in |
New series of N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl) 2-methyl-1H-indole-3-carboxamide derivatives (VIa-d) were prepared and tested for their antibacterial and antifungal activity. The synthesis is based on the condensation of phenylhydrazine and ethyl acetoacetate in the presence of acetic acid to ethyl (2-methyl-1H- indol-3-yl)-2-oxoacetate (III) which on reaction with hydrazine hydrate gives 2-(2-methyl-1H-indol-3-yl)-2-oxoacetohydrazide (IV). Further conden-sation of oxoacetohydrazide and substituted benzaldehyde gave carbohydrazide derivatives (Va-d). Finally addition of triethylamine in dry 1, 4-dioxane and chloroacetyl chloride gave N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl)2-methyl-1H-indole-3-carboxamide derivatives (VIa-d). The structure of newly synthesized 4-Oxoazetidin Substituted derivatives has been established by spectral (IR, 1HNMR) data. These compounds were screened for antibacterial and antifungal activity against various gram-positive and gram-negative strains. All the compounds show significant antibacterial and antifungal...
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Posted by admin on Jan 30, 2016 in |
Acute and chronic inflammation is the most important issue in the field of health. Also, due to the side effects of synthetic drugs, herbal products are widely used in the control of inflammation. In this study was investigated the effect of a hydro-alcoholic extract of Japanese persimmon fruit on the formalin-induced inflammation in the rat paw. 30 male Wistar rats were divided into 5 groups: negative control, group treatment with 300 mg/kg of aspirin (positive control group) and the group’s treated with 200, 400 and 800 mg/kg hydro-alcoholic extract of persimmon, respectively. The inflammation was established to sub-planter injection of 2.5% formalin in rats. Level of inflammation was measured to plethysmometer in six stages in the rat paw. These results were shown that in the rat’s treated with different concentrations of extract; inflammation was lower than the positive control group (p≤0.05). Also, the compression of between groups’ treatment with the extract was determined that reduction of inflammation was as dose depend manner (p≤0.05). We conclude that Japanese persimmon may...
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Posted by admin on Jan 2, 2016 in |
Caryota urens (Palmae) is native to India. This tree species has been of interest to researchers because it is a medicinal plant employed in the indigenous Indian system of medicine. Pharmacognostic standardization, physic-chemical evaluation of the leaves of Caryota urens was carried out to determine its macro-and microscopical characters and also some insoluble ash and sulfated ash values, alcohol- and water-soluble extractive values were determined for phytochemical evaluations. Preliminary phytochemical screening was also done to detect different phytoconstituents. Microscopically, leaf showed lamina, midrib regions, stomata. Powder microscopy showed mesophyll region, pitted xylem vessels and paracytic stomata. TLC of petroleum ether and ethanol extract showed three spots using hexane: ethyl acetate (12:4) and three spots using chloroform: ethyl acetate (5:4). Phytochemically leaves exhibited phytosterols, flavanoids, tannin carbohydrates, and phenolic...
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Posted by admin on Jan 2, 2016 in |
This study was conducted to determine the in-vitro anti-microbial activity of Acacia etbaica, native plant to east African countries, against Staphylococcus aureus and Escherichia coli. To achieve this, the methanol extract of leaf of Acacia etbaica was tested for its in-vitro antibacterial activity against Staphylococcus aureus and Escherichia coli using agar disc diffusion method at two different concentrations (500 µg/disc and 1000 µg/disc). The minimum inhibitory concentration (MIC) of the plant crude extract was also determined using the microdilution method in 96-well plates. Acacia etbaica showed significant antibacterial activity with the mean zone of inhibition of 13.34 ± 1.04 mm and 11.13 ± 1.04 mm in diameter at a concentration of 1000µg of plant extract per disc against S. aureus and E. coli respectively. The MIC of the crude extracts of Acacia etbaica was determined to be 0.039 mg/ml and 0.313 mg/ml against S. aureus and E. coli respectively. The results suggest that the methanol extract of Acacia etbaica could be a rich source of antibacterial compounds. The results...
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