Posted by admin on Oct 31, 2018 in |
In folk medicine, Gendarussa vulgaris Nees (Acanthaceae) is used for the treatment of pain, fever, asthma, rheumatism, colic’s, arthritis, jaundice, inflammation, cephalgia, eczema, diarrhea, wounds, dyspepsia. The present study was designed to evaluate for its safety as well as anti-inflammatory and neuro-pharmacological activities of ethyl acetate extract of Gendarussa vulgaris leaves (EAGVL) by using OECD guidelines, xylene-induced ear edema in mice, pentobarbital-induced sleeping test, open field, and hole cross test. Mortality, a sign of any toxicity or behavioral changes were not observed up to the dose as high as 4000 mg/kg. The crude extract was found to have significant (P<0.05, vs. control) anti-inflammatory activity at the oral dose of 200 mg/kg and 400 mg/kg (b.wt.) in the tested animals. Moreover, the extract of Gendarussa vulgaris leaves potentiated the pentobarbital-induced sleeping time in mice at dose 200 mg/kg and 400 mg/kg. In open field test, the extract at dose 200 mg/kg and 400 mg/kg showed a significant (P<0.05, vs. control) depressant and slight anti-depressant activity. Again, both lower and higher...
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Posted by admin on Oct 31, 2018 in |
Antioxidant potential, phytochemical and growth inhibitory characteristics of Anthocleista vogelii stem bark (AVSB) and root (AVRT), Annona senegalensis stem bark (ANSB) and Waltheria indica leaf (WILV) aqueous extracts were evaluated. Phytochemical analysis showed the presence of flavonoids, tannins, saponins, sterols, alkaloids, and terpenes. Fourier Transform Infra-Red (FT-IR) analyses indicated the presence of O-H, C-H, C=O, C=C, N-H and C-O bonds. AVSB, AVRT, ANSB, and WILV significantly (P<0.001) and dose-dependently (1-32 mg/mL) inhibited Sorghum bicolor seed radicle growth throughout 24-72 h compared with the control seeds. This result indicated the propensity of Anthocleista vogelii (stem bark and root), Annona senegalensis (stem bark) and Waltheria indica (leaf) extracts to inhibit the proliferation of fast-growing cells. The presence of the phytochemicals and the inhibitory activity of the extracts provided a preliminary indication of their cytotoxicity and potential for the management of...
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Posted by admin on Sep 30, 2018 in |
Overexploitation of many traditional medicinal plants like Buchanania lanzan Spreng. has become a threat and shortly, many medicinal plants may be unavailable for use in the medicinal industry. The present study outlines the concept of plant part substitution. Stem bark and small branches of B. lanzan are compared based on physicochemical analysis, phytochemical analysis, total phenolic content, total flavonoid content and High-Performance Thin Layer Chromatography (HPTLC) to evaluate the possibilities of using small branches in place of stem bark. Results suggest that small branches of this plant may be recommended in place of its stem bark after comparison and confirmation of same for pharmacological activities. The study provides the base for further study to use small branches of B. lanzan Spreng. as a substitute for its stem...
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Posted by admin on Sep 30, 2018 in |
Aim of this study was to generate a model of DHNA using protein sequence and homology modeling and then dock the modeled protein with an inhibitor. Molecular docking is a frequently used method in structure-based rational drug design. It is used for evaluating the complex formation of small ligands with large biomolecules, predicting the strength of the bonding forces and finding the best geometrical arrangements. For inhibition of final model built from the swiss model by using target sequence of DHNA from Shigella flexneri and template sequence from E. coli choose 4 types of ligand molecule in which 2 molecules (2-amino pyrimidine and neopterin) selected for docking with the help of Autodock Vina (software). And the final result is shown in docking result 1 and 2 respectively. Docking results shows mean binding energy -3.42 by neopterin and -2.77 by 2-amino, pyrimidine. Neopterin shows high mean binding energy in both of ligands so we can use neopterin as a strong inhibitor of...
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Posted by admin on Sep 30, 2018 in |
The present research was conducted to investigate the anti-inflammatory activity of methanolic extracts of plants of Martynia annua. (Family: Martyniaceae) The anti-inflammatory activity of the methanolic extracts of the Martynia annua at the dose of 50, 100, 200 mg/kg body weight was evaluated against the standard drug – pentazocine at a dose of 25 mg/kg body weight. Adult Swiss albino mice of either sex of six numbers in each group was undertaken for study and evaluated by carrageenan-induced paw edema method. The methanolic extracts of plants of Martynia annua showed greater anti-inflammatory activity when compared with the standard drug. Results of present studies suggest that methanolic extract of Martynia annua significant (P-value < 0.01) anti-inflammatory...
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