Posted by admin on Jul 31, 2019 in |
Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a verity of chemical substances used as a remedy for treating diseases. Anthelmintic and antioxidants have been treated with some medicinal plants or their extract based on folklore medicine. For the research Polygala chainensis and Cleome chelidonii selected based on its availability, high therapeutic value; activity has not been scientifically investigated. Very few pharmacological activities have been reported on whole plant of Polygala chainensis and Cleome chelidonii. The leaves of Cleome chelidonii and Polygala chinensis plants was observed for the phytochemical investigation and pharmacological evaluation. The percentage of yield and phytochemical was observed in methanolic extraction so this extraction was used for pharmacological activity. The extract of Cleome chelidonii and Polygala chinensis plants shown anthelmintic activity. The anthelmintic activity of Polygala chinensis was better than Cleome chelidonii. Significant...
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Posted by admin on Jun 30, 2019 in |
Two indigenous plants Clerodendrum colebrookianum walp and Centella asiatica Linn. were selected to determine its cardioprotective activity on male Wister albino rats. Empirical research was designed to evaluate the cardioprotective activity of the leaves of both with special reference to its putative protective role. Aqueous methanolic extracts of both the plants were prepared by continuous hot percolation method. Male albino rats of Wistar strain (250-300 g) were used for the study. Animals were divided into 10 groups of six animals each. Both pretreatment and post-treatment study was done for 16 days at two different doses of 300 mg/kg body weight and 700 mg/kg body weight, respectively. Carbon tetrachloride was used as a cardiotoxic agent. The in-vivo biological studies on serum and tissues of male Wister rats at the doses of 300 mg and 700 mg/kg body weight respectively was carried out taking silymarin as standard. The methanolic extract of both improved the cholesterol level along with significant improvement of SGPT (Serum glutamate pyruvate transaminase), SGOT (Serum glutamate oxaloacetate transaminase),...
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Posted by admin on Jun 30, 2019 in |
The present study was carried out to evaluate the wound healing potential of ethanolic flowers extract of Bauhinia acuminata in two different types of wound models in Albino rat viz., incision and excision, and compare the effects with standard drug povidine iodine ointment. The ethanolic extract at a dose of (250 mg/kg) possesses a significant increase in wound contraction and formation of scar in an excision wound model. The extract showed a significant increase in the breaking strength of resutured incision wound as compared to the control group (p<0.05). The result of the present study indicates that ethanolic flowers extract of B. acuminata posses significant wound healing in excision and incision wound model. The presence of phytoconstituents like flavonoids, saponins, phenols either individually or combined may exhibit the synergistic effect towards the healing of...
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Posted by admin on Jun 30, 2019 in |
Environmental pollutants apart from other factors like habitat loss and interventions of invasive species, is regarded as a likely cause towards a worldwide decline in amphibian population. The present study attempts to elucidate the toxicity of commercially formulated malathion (MAT) by investigating biochemical aspects in Dattaphrynus melanostictus tadpoles. Three sublethal concentrations of MAT (1.0, 1.8, and 2.5 mg/l) were considered to which the tadpoles (Gosner stage 27) were exposed for five days. The outcome of the present investigation revealed a significant decline (P<0.05) in activities of catalase, superoxide dismutase, glutathione peroxidase while suggesting a significant elevation in lipid peroxidation. The inhibition acetylcholinesterase activity confirmed MAT as anticholinesterase product. The overall outcome of the present investigation suggests the toxic potentials of MAT; which could have possibly resulted in compromised antioxidant status and neurobiochemical makeup of the exposed tadpoles. Thus, based on the results obtained, it could be ascertained that the commercial grade MAT may pose a potential threat to the tadpoles of D. melanostictus under the selected sublethal concentrations. The...
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Posted by admin on Jun 30, 2019 in |
Introduction: The objective of the present work was to study the antidiabetic effect of ethanolic extract of Murraya koenigii stem bark (EEMK) in alloxan-induced diabetic rats. Materials and Methods: Male Wistar albino rats weighing between 150-250 g were used for this study. The rats were divided into five groups (n=6). Group, I served as the diabetic control, group II served as diabetic control, groups III, IV served as test groups, and group V served as a standard group. The diabetes was induced by a single dose of alloxan (140 mg/kg, i.p.) in all the groups except normal control group. Then the rats of respective groups were treated with normal saline, EEMK (125 mg/kg and 250 mg/kg) and metformin (50 mg/kg) for 11 days. Blood glucose estimation was performed on 0, 1, and 11 days. At the end of this study period, animals were sacrificed for studying biochemical parameters. Results: Alloxan-induced diabetic rats showed marked hyperglycemia at the end of the study period. Body weight and liver glycogen levels were...
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