Posted by admin on Sep 30, 2018 in |
Background: Sickle cell anemia continues to be prevalent in the African population of which Nigeria alone has epidemiology of 25%, and only a few official medications are available, necessitating this current study. Methods: Cnestis ferruginea Vahl ex DC., Connaraceae, Alcornea laxiflora (Benth.) Pax & K. Hoffman Euphorbiaceae, and Spathodea campanulata Beauv., Bignoniaceae, which have various uses ethnomedicinally in Nigeria were extracted using a cold method of extraction with absolute methanol. The abilities of the extracts individually and in combination, to inhibit or reverse sickling of erythrocytes in-vitro at low oxygen tensions according to the modified methodology of Dean and Schechter, 1978 were examined. Results: While C. ferruginea leaf gave 94.6% sickling reversal activity at 4 mg/ml, S. campanulata gave reversal activity of 89.6% at 4 mg/ml, and A. laxiflora leaf gave the highest sickling inhibitory activity of 98.8% at 8 mg/ml. The combination of A. laxiflora leaf and C. ferruginea leaves when extracted together at ratio 1:2 gave an inhibition activity of 91.7% at 4mg/ml and 93.5% inhibition at...
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Posted by admin on Sep 30, 2018 in |
Aim of Study: Compare the phyto-pharmacognostical study of Acacia arabica and Prosopis juliflora. Material and Methods: The ethanolic extract of on Acacia arabica and Prosopis juliflora were using physio-chemical parameters and preliminary phytochemical investigation. Results: The present study was aimed at pharma-cognostical study. Plants Acacia arabica and Prosopis juliflora were studies for pharmacognostical characteristic, namely, morphology, microscopy, physicochemical, parameters which can be of utilized in identification and authentication of plants. Methanolic extracts used for the HPTLC analysis. Several medicinal properties have been scientifically established by various workers. Conclusion: In this study, I have done the comparative pharmacognostic study on Acacia arabia and Prosopis juliflora and conclude that the ethanolic extract of Acacia arabica plays a more significant role and has more significant value than the extract of Prosopis...
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Posted by admin on Sep 30, 2018 in |
Gardenia resinifera Roth. is a medicinal plant belonging to family Rubiaceae. It is an important traditional medicinal plant employed in various indigenous system of medicine against several diseases. The current communication provides pharma-cognostic, physicochemical and phytochemical investigation carried out on the leaves of Gardenia resinifera Roth, which are useful in setting some diagnostic indices for the identification and preparation of a monograph of the...
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Posted by admin on Aug 31, 2018 in |
The qualitative estimation of herbal formulation Lohasava, is of principal importance to justify their adequacy in the present system of medicine. One of the key problems which are faced by the herbal drug industry is the unavailability of rigid quality control profiles for herbal materials and their formulations. Regulatory bodies have such as WHO, AYUSH, ICH, etc., had laid down the standardization and specifications parameters for various Ayurvedic preparations. The present Investigation evaluated different brands of Lohasava available in the market as per WHO and Indian Pharmacopoeial specifications. Various physicochemical parameters such as Loss on drying, total ash, sugar content, alcohol content, and microbial content were determined. The result reveals that all the preparations contain acceptable levels of alcohol (less than 12%...
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Posted by admin on Aug 31, 2018 in |
Cytotoxicity of lipopolysaccharide (LPS) as a bacteria-related compound and paraquat (PQ) as a non-bacterial toxicant on freshly isolated alveolar macrophages (AMs) was studied. At the same time, preventive, protective and therapeutic effects of quercetin (QCN) against LPS-induced and silymarin (SMN) against PQ-produced cytotoxicity as known antioxidants with potent anti-inflammatory property were also investigated. Freshly isolated rat’s AMs were exposed to low, medium and high concentrations of LPS (1, 5 and 10 µg/ml), PQ (1, 5 and 10 µg/ml), QCN (1, 5 and 10 µg/ml) and SMN (25, 50 and 100 µg/ml), separately. After that, the effective concentration of LPS/PQ along with low, medium and high concentrations of QCN/SMN in the forms of preventive, protective and therapeutic was evaluated on cell viability, lactate dehydrogenase activity (LDH), nitric oxide content and total antioxidant capacity (TAC) of alveolar macrophages. Results showed that both LPS and PQ in a concentration-dependent manner reduced the cell viability and TAC values and elevated the NO content and LDH concentration. By contrast, QCN and SMN administration alone...
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