Posted by admin on Jan 31, 2019 in |
It is known that Eclipta alba Hassk. (Family: Compositae) contains coumestans (Wedelolactone and dimethyl wedelolactone) are used in liver disorders. The objective of the present investigation was to develop a novel formulation of these coumestans in combination with the soya phosphatidylcholine (PC), to overcome the limitation of absorption and to investigate the protective effect of the coumestans-phosphatidylcholine complex (C-PC) on carbon tetrachloride-induced acute liver damage in rats. Methanolic extract (ME) of the whole plant of Eclipta alba was fractionated with water and then with ethyl acetate. The ethyl acetate fraction of methanolic extract (EFME) contains coumestans which were characterized by chemical tests. EFME and PC prepared the C-PC. FT-IR and DSC spectroscopy characterized the C-PC. In-vitro drug release from EFME and C-PC through egg membrane was performed using UV-Visible spectrophotometer. The hepatoprotective activity of C-PC (Equivalent to 5.35 and 10.7 mg/kg body weight of EFME), ME 250 mg/kg and EFME 5.35 mg/kg were evaluated on various enzymes level. C-PC significantly provided better protection to the liver by restoring the...
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Posted by admin on Jan 31, 2019 in |
Holostemma ada kodien is one of the potential indigenous medicinal plants belonging to the family Asclepiadaceae distributed through the south Indian region. Traditionally, it is used for a laxative, ulcer treatment, blood purifier, itching, leucoderma, gonorrhea. The most important medicinal uses of the plant are Antipyretic, antioxidant, anti-diabetics, hepatoprotective. The objective of this study was to evaluate the anthelmintic activity of macerated ethanolic extracts of roots. Preliminary phytochemical investigation show the presence of Alkaloids, phenols, saponins, tannins, flavonoids, steroids, anthocyanins. The data revealed that the ethanolic extract showed anthelmintic activity at concentration 50 mg/ml. The paralysis time and death time of ethanolic extract was found to be less than that of standard drug. Allopathic drugs have serious side effect development of resistance; the herbal remedies can be a superior alternative for...
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Posted by admin on Jan 31, 2019 in |
Considering the prevalence of epilepsy and the problems associated with currently available antiepileptic drugs like side effects, resistance, safety issues and high cost, herbal medicines with fewer complications could be very appropriate alternative. Therefore, in the present study, we have examined the antiepileptic properties of ethanolic extract of Rhododendron arboreum leaves in mice using maximal electroshock seizure (MES) test, Pentylenetetrazole (PTZ) induced seizures, Strychnine induced convulsion and brain amine estimation method. The ethanolic extract at 200 mg/kg and 400 mg/kg possess dose- dependent anticonvulsant activity as it reduced the duration of seizures produced by maximal electroshock and delayed the latency of seizures produced by PTZ and Strychnine. The amount of Dopamine and Nor-adrenaline which are most likely to be involved in seizure activity was increased in mice...
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Posted by admin on Jan 31, 2019 in |
Polyphenols are secondary metabolites found in all vascular plants. Red grapes are one of these plants rich in these substances. The main objective of this study was to trace the polyphenolic compounds profile of red grape leaves from various Western regions of Algeria and to study their antioxidant activity. A spectrophotometric assay of the main phenolic groups and a chromatographic assay by HPLC-DAD and HPLC-FLU were carried out. The screening of anti-oxidant power was also performed by phosphomolybdenum method and DPPH assay. The results showed that all the studied leaves samples are rich in phenolic compounds with differences from one region to another. Polyphenol contents varied from ± 246 ± 18.93 to 923 ± 88.06 mg Eq gallic acid/g.dw. The HPLC assay identified the polyphenolic compounds profile of the studied samples. The antioxidant activity was widely covered and highlighted; the leaves extract of Aïn Temouchent sample is the most active with an EC50 in the DPPH test of 0.08 mg/mL, which is higher than EC50 of ascorbic acid. This...
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Posted by admin on Jan 31, 2019 in |
Introduction: Infection due to antimicrobial resistance is currently one of the major threats to mankind. This study investigates the antimicrobial activity of the various extracts of the stem bark of Maesobotrya dusenii (Pax) Hutchinson (Euphorbiaceae). Methods: Pulverized 100 g of stem bark of M. dusenii extracted with methanol. Another 400 g of the plant material was also successively macerated with n-hexane, ethyl acetate, and methanol. These extracts were assessed for antimicrobial activity on clinical isolates of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using agar diffusion method and minimum inhibitory concentration was determined. Ciprofloxacin was used as a standard antibacterial drug, while ketoconazole was used as a standard antifungal drug. Results: The ethyl acetate extract was the most active extract on E. coli with a minimum inhibitory concentration (MIC) of 0.025 mg/mL. The n-hexane extract also exhibited activity on E. coli with MIC of 0.196 mg/mL. Only n-hexane extract was active against Candida albicans with a MIC of 12.5 mg/mL. Conclusion: The ethyl acetate extract was active...
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