THE MECHANISTIC APPROACH OF THE PROPYLENE GLYCOL AS A CO-SURFACTANT THROUGH “SIX MEMBER CYCLIC HYDROGEN BONDING SYSTEM” FOR THE STABLE AND FLEXIBLE MICROEMULSION DRUG CARRIERAbstract
The improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and concluded with the plausible mechanism of hydrogen bond donor/acceptor felicitator to the surface active molecule by the hydrogen bonding with the surfactant polar head group to increase the fluidity of the system. Through this unique mechanism, the co-surfactant expands the area of existence of microemulsion. The system allows the topical drug with the stable as well as a flexible system with higher drug entrapment. The systems aligned toward the liquid crystal phase than the liquid phase, which makes the system more convenient for the delivery system.
P. Saxena *, P. K. Sharma and P. Purohit
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Gautam Budh Nagar, Uttar Pradesh, India.
13 April 2019
20 May 2019
26 May 2019
31 May 2019