THE MECHANISTIC APPROACH OF THE PROPYLENE GLYCOL AS A CO-SURFACTANT THROUGH “SIX MEMBER CYCLIC HYDROGEN BONDING SYSTEM” FOR THE STABLE AND FLEXIBLE MICROEMULSION DRUG CARRIER
AbstractThe improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and concluded with the plausible mechanism of hydrogen bond donor/acceptor felicitator to the surface active molecule by the hydrogen bonding with the surfactant polar head group to increase the fluidity of the system. Through this unique mechanism, the co-surfactant expands the area of existence of microemulsion. The system allows the topical drug with the stable as well as a flexible system with higher drug entrapment. The systems aligned toward the liquid crystal phase than the liquid phase, which makes the system more convenient for the delivery system.
Article Information
3
172-180
960
493
English
IJP
P. Saxena *, P. K. Sharma and P. Purohit
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Gautam Budh Nagar, Uttar Pradesh, India.
pratikshascholar.m.pharm@gmail.com
13 April 2019
20 May 2019
26 May 2019
10.13040/IJPSR.0975-8232.IJP.6(5).172-80
31 May 2019