Posted by admin on Jun 30, 2019 in |
Introduction: The objective of the present work was to study the antidiabetic effect of ethanolic extract of Murraya koenigii stem bark (EEMK) in alloxan-induced diabetic rats. Materials and Methods: Male Wistar albino rats weighing between 150-250 g were used for this study. The rats were divided into five groups (n=6). Group, I served as the diabetic control, group II served as diabetic control, groups III, IV served as test groups, and group V served as a standard group. The diabetes was induced by a single dose of alloxan (140 mg/kg, i.p.) in all the groups except normal control group. Then the rats of respective groups were treated with normal saline, EEMK (125 mg/kg and 250 mg/kg) and metformin (50 mg/kg) for 11 days. Blood glucose estimation was performed on 0, 1, and 11 days. At the end of this study period, animals were sacrificed for studying biochemical parameters. Results: Alloxan-induced diabetic rats showed marked hyperglycemia at the end of the study period. Body weight and liver glycogen levels were...
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Posted by admin on Jun 12, 2019 in |
A study on nutritional and microbial analysis of Kunapajala with different storage interval was conducted in the Department of Soil Science & Agricultural Chemistry and Department of Plant Pathology, UBKV, Coochbehar – 736165, West Bengal during March 2019. The motive of this work was to estimate the physicochemical properties, macro, and micronutrient content, and various microbial load of Kunapajala with a different storage time interval. Kunapajala was rich in N, P, K, Ca, Mg, S, Fe, Zn, Cu & Mn and it had a significant beneficial microbial load of Fungi, Actinomycetes, Pseudomonas, solubilising phosphorus bacteria (PSB), Azotobacter, Azospirillum, Rhizobium and Trichoderma. Nutrient content and microbial population change significantly with time in Kunapajala. So, continuous foliar and soil application of Kunapajala from the beginning and up to 40 days after preparation was beneficial to get maximum utilization. It is recommended that Kunapajala can be used as an alternative against chemical fertilizers and pesticides to develop organic...
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Posted by admin on May 31, 2019 in |
The current study was aimed to investigate the analgesic activity of the methanolic extract of Amaranthus spinosus leaf (Family: Amaranthaceae). The analgesic activity was assessed with this extract for their peripheral and central anti-nociceptive potentials using three standard test methods, for instance, acetic acid induced writhing, hot plate and tail immersion methods in Swiss albino mice, at the doses of 200 and 400 mg/kg body weight. In acetic acid induced writhing method, methanolic extract of Amaranthus spinosus leaf (200 and 400 mg/kg) showed significant peripheral analgesic activity with writhing inhibition of 58.02% and 63.2% respectively whereas the standard drug diclofenac-Na (25 mg/kg) showed 73.88% writhing inhibition. In the hot plate test, methanolic extract of the leaf (200 and 400 mg/kg body weight) showed 55.09%, and 66.22% central nociception inhibition of thermal stimulus respectively, where the standard drug morphine (5 mg/kg) displayed 50.35% nociception inhibition. In the tail immersion test, maximum 68.19% and 73.91% nociception inhibition of thermal stimulus was exhibited with methanol extract of the leaf (200 and 400...
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Posted by admin on May 31, 2019 in |
Amaranthus spinosus, belongs to Amaranthaceae family, is an annual or perennial herb grows annually; native to tropical America and found throughout India as a weed in cultivated as well as fallow lands. Though the whole plant is used as a laxative, the roots are regarded as highly specific for colitis, and it is also used as antipyretic, febrifuge, diuretic. Other than its culinary value, it is utilized in the treatment of bronchitis, digestible, appetizer, biliousness, haematinic, galactagogue, stomachic, flatulence, nausea, anorexia, blood diseases, leucorrhoea, burning sensation, leprosy, and piles. This study aimed to investigate the anti-nociceptive activity of the ethanol extract of the root of Amaranthus spinosus Linn. The anti-nociceptive activity was investigated for its peripheral and central pharmacological action using acetic acid-induced writhing, hot plate, and tail immersion methods in Swiss albino mice at the doses of 200 and 400 mg/kg body weight. Ethanol extract of the root (200 and 400 mg/kg) showed the most significant anti-nociceptive activity in acetic acid induced writhing method with writhing inhibition of...
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Posted by admin on May 31, 2019 in |
The improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and concluded with the plausible mechanism of hydrogen bond donor/acceptor felicitator to the surface active molecule by the hydrogen bonding with the surfactant polar head group to increase the fluidity of the system. Through this unique mechanism, the co-surfactant expands the area of existence of microemulsion. The system allows the topical drug with the stable as well as a flexible system with higher drug entrapment. The systems aligned toward the liquid crystal phase than the liquid phase, which makes the system more convenient for the delivery...
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