Posted by admin on Oct 31, 2024 in |
The purpose of this work was to develop a novel topical formulation of econazole nitrate based on gel that can be easily scaled up in one pot for the potential treatment of fungal and yeast infections. Econazole nitrate is a topical antifungal, used to treat tinea versicolor, tinea pedis, and tinea cruris. Compared to applying cream or ointment, topical gels offer numerous advantages, one of which is that the drug is released more quickly to the intended site of action. A viscous mixture of propylene glycol, Triethanolamine, methyl paraben, and econazole nitrate were mixed together before being formulated into the optimized gel bases. The gel’s color, appearance, and homogeneity were assessed visually. For every formulation, the drug content, pH, viscosity, spreadability, and gel strength were characterized. The manufactured formulations were transparent, half white, pale yellow, and exhibited excellent homogeneity. The pH and viscosity are within the limit. The drug diffusion of F1 93.81, F2 97.56, F3 92.36, F4 90.95, F5 93.18 and F6 90.14. From among all the developed...
Read More
Posted by admin on Oct 10, 2024 in |
Phytochemicals are plant-derived bioactive substances that are extensively used in conventional herbal treatment. The locals employ these herbal remedies to treat a wide range of illnesses, including serious conditions like diabetes mellitus, cancer, HIV and others. The current study’s goals were to screen for these phytochemicals and assess the antibacterial efficacy of methanolic and ethanolic extracts from Portulaca oleracea and study of antibacterial activity of leaf extracts from Portulaca...
Read More
Posted by admin on Oct 10, 2024 in |
This study aims to shed light on the plant Ecballium elaterium (L.) A. Rich., Flora of Palestine, which belongs to the Cucurbitaceae family, in terms of the chemical composition of its leaves, flowers, fruits, seeds, and roots. The chemical study of various extracts from leaves flowers, seeds, fruits and roots from Ecballium elaterium (L.) A. Rich. for biologically active compounds was carried out using multiple types of specific chemical reactions and multiple types of chromatographs. As a result of chemical examination of biologically active compounds from members of the Ecballium elaterium plant, which is widespread in Palestine, the presence of the following active substances was proven for the first time: triterpenoids, alkaloids, tannins, phenols, flavonoids, and amino...
Read More
Posted by admin on Oct 10, 2024 in |
Chitosan, a biopolymer derived from chitin, has garnered significant attention due to its unique properties, eco-friendly nature, and diverse applications in various industries owing to its remarkable properties. This study focuses on the extraction and characterization of chitosan from giant African snail shells. Various experiments were designed to optimize the extraction process, resulting in a chitosan yield of 61.37%, a moisture content of 2.02%, and a degree of deacetylation (DD) of 68.24%. The physicochemical properties of the extracted chitosan nanoparticles were characterized, revealing important parameters for its potential applications. Fourier Transform Infrared Spectroscopy (FTIRS) analysis indicated the presence of functional groups such as O-H, N-H, C≡C, C=C, and N-H bending, corroborating previous studies. Scanning Electron Microscopy (SEM) revealed the chitosan particles’ polygonal shape and rough surface, suggesting their suitability for adsorption applications and heavy metal trapping. X-ray Diffraction (XRD) analysis demonstrated a semi-crystalline nature of the chitosan, with a sharp peak at 34° (2θ) and other suppressed peaks. These findings confirm the successful synthesis of chitosan from giant African...
Read More
Posted by admin on Oct 10, 2024 in |
Mosquitoes are the major deadliest insects in the world which cause the number of vectors borne diseases (e.g., Dengue, malaria, Zika virus fever, yellow fever, west Nile fever, Japanese encephalitis) in human being. In present years, interest in plant-based products has been revived because of the development of resistance, cross-resistance and possible toxicity hazards associated with synthetic insecticides and their rising costs. Presently available mosquito repellent in the market is based on the chemical and they aretoxic against the skin and nervous system, thereby they cause skin rashes, swelling, eye irritation, and other health problems. So, to overcome these herbal products are more preferred than chemical-based mosquito repellents. Herbal materials belonging to different plant species and their mixtures have been seen to act as effective repellent against various mosquitoes and pests. The easy availability and less adverse environmental impact have led to the increased interest in plant origin repellants which are safe and biodegradable alternatives to synthetic chemical repellants for use against mosquitoes and pests. The easy availability and...
Read More
