Posted by admin on Apr 30, 2021 in |
Objective: Plants live on a planet with days and seasons, affecting their phytoconstituents. The challenge is that availability of active principles in medicinal plants changes by seasonal fluctuations, so their dose pattern for therapeutic efficacy also get influenced. The best duration for the harvesting of specific secondary metabolites for better yield is not fixed. Seasonal impact show changes in important constituents like polyphenol, flavonoids, glycosides, alkaloids, essential oil, etc. Late summer is the best collection time for essential oil components. Winter and rainy are the best season for other secondary metabolites. Methods: The selected plant Azadirachta indica A. belongs to the alkaloidal category with having anti-diabetic activity. Plants were evaluated for pharmacognostic study, which includes macroscopic and microscopic evaluation, determining physicochemical parameters systematically. HPTLC fingerprinting for nimbin was done. The study was performed for plant material with three different seasons, and the best results were analyzed. Results and Conclusion: All the plants showed correct taxonomy with specific morphological, microscopical, and physicochemical parameters, which is helpful for the standardization of...
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Posted by admin on Apr 30, 2021 in |
Alzheimer’s syndrome/disease is known for its progressive Neuro-degenerative illness and considered pathologically by the deposition of β-amyloid peptide and senile plaques (a pathological accumulation of paired helical filament composed of abnormally formed tau protein in the hippocampus of our brain). This serves to maintain the memory deterioration. Along with that, the treatment and prevention of synthetic drugs having a long list of adverse effects. Alzheimer’s syndrome induced through aluminium trichloride (4.2 mg/kg intraperitonial) continues for 28 days. The albino Wistar rats were divided into 5 groups (n=6 in each group) then weighed for 28 days of induction of disease. Extract of dried leaves of Camellia sinensis. (200 mg/kg and 400 mg/kg) along with standard drug (Donepezil 2 mg/kg) by oral route given through (1% CMC suspension) after treatment showed a significantly decreased escape latency. Previous studies for Camellia sinensis showed that it is efficient in the prevention of deposition of senile plaques. Along with neurofibrillary tangles in the hippocampus with deficits in enhanced memory...
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Posted by admin on Apr 30, 2021 in |
Anaemia globally affects 1.62 billion peoples in the world. To treat anaemia, Hibiscus acetosella is sometimes used traditionally. This study has been conducted to evaluate the anti-anaemic effects of the aqueous leaves extract of Hibiscus acetosella, on two experimental models of anaemia. Bleeding anaemia was induced by retro-orbital puncture of 2-2.5 mL of blood during two days, while haemolyticanaemia was induced by intra-peritoneal injection of 2. 4 dinitro-phenylhydrazine (40 mg.kg bw) during 7 days. After induction, plant extract (100; 200 or 400 mg.kg bw) was daily administrated by oral route for 14 days. During experience, haematological analysis was done at the beginning, at the end of induction and every week during treatment. During haemolytic anaemia; aqueous extract significantly increased haematocrit and red blood cell with the maximum of 45% and 32% respectively at the dose of 400 mg.kg.bw; haemoglobin significantly increased in rats with a maximum of 32% at the dose of 200 mg.kg bw. In bleeding anaemia model, H. acetosella significantly increased the haematocrit as well as red...
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Posted by admin on Apr 30, 2021 in |
Six phenolic acids -chlorogenic acid (1), caffeic acid (2), 4,5 di-O-caffeoylquinic acid (3), 3,5 di-O-caffeoylquinic acid (4), 3,4 di-O-caffeoylquinic acid (5) and 3,4,5-tri-O-caffeoylquinic acid (6) were identified by HPLC-UV-MS from the roots of Cephalaria gigantea (Dipsacaceae) growing in Georgia. The aim of the present research was a qualitative identification of phenolic constituents in an anticonvulsive enriched fraction from the roots of C. gigantea, for further quantitative standardization. The HPLC profile demonstrated a good resolution of phenolic acids of the active extract within 25 min of gradient mode (ACN 5% to 40%). On the basis of retention times, using the UV and MS spectra of the corresponding standards, compounds 4 and 5 were found to be majors in the analyzed fraction and were reported for the first time from C. gigantea roots. These experimental data could be a solid base for the future quantitative standardization of the anticonvulsive fraction for the prevention and treatment of psychosomatic forms of...
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Posted by admin on Mar 31, 2021 in |
Aim: To investigate the hepatoprotective activity of Morus alba Linn. alcoholic leaves extracts against paracetamol-induced hepatitis in rats. Materials and Methods: The Morus alba leaves extracted with alcoholic (ALE), and water extract (AQE) against Paracetamol induced hepatotoxicity and using Standard drug is Liv-52. Preliminary phytochemical tests were done. Results: The ALE showed presence of alkaloids, flavonoids, carbohydrates, tannins, and steroids, did not produce any mortality. Paracetamol produced significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP) and serum bilirubin.), histological (damage to hepatocytes) using Standard drug Liv-52. Pre-treatment with ALE extract significantly prevented the biochemical and histological changes induced by Paracetamol in the liver. Conclusion: The present study shows that the ALE extract possessed hepatoprotective activity....
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