IN-SILICO AND IN-VIVO EVALUATION OF A TOPICAL FORMULATION CONTAINING CREATINE MONOHYDRATE FOR THE MANAGEMENT OF CHRONIC DIABETIC WOUNDS IN MALE WISTAR RATS
AbstractChronic diabetic wounds are a common complication in individuals with diabetes and can lead to severe health issues if not treated quickly. Due to its capacity to improve cellular energy metabolism, Creatine monohydrate (CrM) has been suggested to possess potential health benefits. The effectiveness of a topical CrM formulation in healing chronic diabetic wounds in male Wistar rats was investigated in this research along with placebo, marketed formulation. Over the course of 21 days, the reduction of the wound and its fast pace of healing were observed. In contrast to the disease control group, the treatment group lesion size was significantly reduced and its wound closure rate was significantly higher. Increased collagen deposition and angiogenesis were also found by histological analysis in the CrM group, suggesting improved tissue regeneration. In conclusion, the topical CrM formulation showed encouraging benefits on wound healing and may have application in the therapeutic management of chronic diabetic wounds.
Article Information
10
569-576
1587 KB
154
English
IJP
S. L. Bajaj, M. V. Kadwaikar, Malti Salunke, Amol Muthal, Ravindra Kulkarni and V. M. Shinde *
Department of Pharmacognosy, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.
vaibhavshinde847@gmail.com
12 September 2024
28 September 2024
29 September 2024
10.13040/IJPSR.0975-8232.IJP.11(10).569-76
31 October 2024
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