Posted by admin on Jun 30, 2020 in |
Argemone mexicana is an indigenous herb commonly known as Prickly poppy. It belongs to the family Papaveraceae. Argemone mexicana is noted to possess medicinal benefits in the traditional system of medicine. Various parts of the plant were widely used in Ayurveda, Siddha, Unani and Homeopathic medicines. It is reported to have antimicrobial Activity, wound healing property, larvicidal and chemo sterilant activity, nematicidal and allelopathic potential, anti-malarial, antibacterial and antifungal, molluscicidal, anti-cancer, hepatoprotective, anti-HIV and neuro-pharmacological activity. Beyond pharmaceutical efficacies, certain plant parts also show toxic effects as well. Argemone Mexicana oil adulteration poses a serious threat to human health and should be checked by appropriate regulatory measures. Hence, up-to-date information on the chemical and pharmacological knowledge on this plant may be helpful to guide researchers anticipating to undertake further investigations in these...
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Posted by admin on Jun 30, 2020 in |
The present work has been done with an objective to analyze the crude drug parametrs responsible for tenable antioxidant effect of leaf, stem and root of Glycosmis pentaphylla (Retz.) DC. Fresh leaf, stem and root of Glycosmis pentaphylla were extracted with ethanol (EEGPle, EEGPst, EEGPro). The antioxidant profiling was done through different methods like 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, 2,2-azino-bis-3-ethyl benzothiazoline acid (ABTS) free radical scavenging assay and nitric oxide (NO) free radical scavenging assay. Crude drug parameters were focussed mainly on micrometric properties so as to determine the flow properties when consumed for medicinal purposes. A significant antioxidant activity was revealed by the EEGPle [EC50: (29.04±0.008) µg/mL], compared to EEGPst and EEGPro in DPPH assay. The ranking order for ABTS was EEGPle > EEGPst > EEGPro. The EC50 value of NO of the EEGPle, EEGPst and EEGPro were (263.14±0.05) µg/mL, (312.62±0.07) µg/mL and (384.62±0.006)µg/mL respectively. Quantity of TFC and TPC were highest in EEGPle (112.96±3.89 mg QRE/g and 96.6±1.08 mg GAE/g extract) rather than EEGPst and EEGPro...
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Posted by admin on Jun 30, 2020 in |
Bi-layer tablets are developed to get immediate and sustained delivery of various drugs that have pre-defined release. In the past few decades, development in a combination of active pharmaceutical ingredients (API) in a single fixed dosage form has increased in the pharmaceutical industry, also promotes patient convenience and compliance. Bi-layer tablet plays a crucial role in the development of controlled release in order to give a successful drug delivery. Bi-layer tablets can be said to be a better option to reduce chemical incompatibilities taking place between Active Pharmaceutical Ingredients and to enable the development of various drug release profiles. Bi-layer tablet suits for sequential release of two drugs in combination or to incorporate two incompatible substances in same tablet. The bi-layer tablets are preparing by using different techniques such as OROS® push-pulls Technology, L-OROSTM Technology, EN SO TROL Techno-logy. This review article explains various techniques of bi-layer tablets and why the development and production of quality bi-layer tablets need to be carried out and basic challenges faced during the...
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Posted by admin on Jun 30, 2020 in |
Urolithiasis is a complex process that occurs from the various physiochemical event, including super-saturation aggregation, nucleation, growth, nucleation within the kidney. Data from different types of studies revealed that phytomedicines useful as an alternative remedy for the management of Urolithiasis. Terminalia chebula has been reported to possess antiurolithiatic property. The fruits were extracted in aqueous by maceration. In-vitro study was conducted to study the anti-urolithiatic effect of fruits of a macerated aqueous extract with standard drug Cystone. The titrimetric method was performed to evaluate the dissolution of stone crystal. Aqueous extract of fruits of Terminalia chebula proved a significant effect compared with standard drug Cystone. Aqueous extract of fruits of Terminalia chebula dissolves 48% crystal while Cystone dissolved 62% calcium oxalate crystal in an in-vitro...
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Posted by admin on Jun 30, 2020 in |
Introduction: Picrorhiza kurroa is a well-known plant used in Ayurvedic medicines belonging to the family, Scrophul-ariaceae. This herb has been traditionally used in treating liver disorders, upper respiratory tract disorders, reduce fever, scorpion stings, and treat dyspepsia and chronic diarrhea. Experiment: The macroscopy, microscopy, powder microscopy, physiochemical screening was done on Picrorhiza kurroa roots. TLC, HPTLC. Results: The macroscopy, microscopy, and powder microscopy study reveals the identification of P. kurroa root. The phytochemical studies showed the presence of secondary active constituents such as phenols, glycosides, etc., TLC and HPTLC analysis showed that the chloroform fraction of P. kurroa has a higher number of peaks and spots compared to total...
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