Posted by admin on Dec 31, 2019 in |
To analyze the efficacy of topical nepafenac, 0.1% eye drops in the treatment of diabetic macular edema (DME). Method: a prospective interventional study in 14 eyes having center involving DME were taken into consideration. They were administered topical nepafenac eye drops 0.1% thrice daily for 6 months. Their vision and foveal thickness were recorded systematically at the start of the treatment and then at 2nd, 4th, and 6th month follow up. Results: The mean baseline and final Log MAR visual acuity were 0.33 and 0.15, respectively and the mean baseline and final foveal thickness were 450 µm and 290 µm respectively. Conclusion: A statistically significant improvement was noticed in the visual acuity and foveal thickness after the administration of 0.1% of topical nepafenac eye...
Read More
Posted by admin on Dec 31, 2019 in |
Natural compounds have already contributed to the discovery of new anti-malarial drugs. Atovaquone, artemisinin and its semi-synthetic derivatives as well as clindamycin, erythromycin, azithromycin, chlortetracycline, tetracycline, oxytetracycline and doxycycline, are noteworthy examples of the varied contribution of natural products for the development of effective anti-malarial drugs, particularly valuable for the treatment of chloroquine-resistant parasites. To avoid side effects and the resistance developed by the synthetic drug natural drug preffered. However, in many cases good activity and selectivity were observed. Most importantly, several compounds containing unique structural composition have been isolated and characterized. In the present review, a number of potential anti-malarial plants explored have been brought out, and a number of leads suggested on the basis of their anti-malarial activities. Thus, it provides guidance for areas of further research on potential plant resources that could be sources of compounds with therapeutic properties for the treatment of malaria. Some of the plants were investigated for anti-malarial activities, and their efficacy, toxicity, and safety aspects still need to be...
Read More
Posted by admin on Dec 31, 2019 in |
Herbs are used as a source of medicine in Ayurveda and also in some traditional systems of medicine as having lesser side effects and cost when compared with synthetic drugs. Plants live on a planet with days and seasons, and that affects their phytoconstituents. The availability of active principles in medicinal plants changes by seasonal fluctuations, so their dose pattern for therapeutic efficacy also gets influenced. The best duration for the harvesting of specific secondary metabolites for better yield is not fixed. Seasonal impact show changes in important constituents like polyphenol, flavonoids, glycosides, alkaloids, and essential oil. Late summer is the best collection time for essential oil components. Winter is the best season for the harvesting of secondary metabolites containing plant parts. The results of these studies may help the researcher those who are involved in exploring the isolation of valuable chemicals from the plants for the treatment of various diseases. Therefore, the current review aims to focus on the best possible season for the harvesting of pharmaceutically important...
Read More
Posted by admin on Dec 31, 2019 in |
Plants and fruits have medicinal purposes, and they are being used long before the prehistoric period. Among the different varieties of citrus fruits, Citrus aurantifolia (Kagoji labu) is widespread in tropical and subtropical regions around the World. It is one of the major citrus fruits and widely consumed, but there is limited evidence about its health-promoting properties. In the present study, we evaluated the phytochemical and antioxidant properties of this citrus fruit since phytochemicals through anti-oxidant properties have played a significant role in human health protection and treatment of many diseases. Polyphenol, flavonoid, tannin and reducing sugar contents were found 4.68 ± 0.36 g GAE / 100 g extract, 615.38 ± 17.75 mg CE / 100 g extract, 12.5 ± 6.25 g TAE / 100 g extract and 51.69 ± 7.50 g GE / 100 g extract, respectively. Significant antioxidant activities of C. aurantifolia via 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were detected. Earlier studies have reported that almost all species of citrus...
Read More
Posted by admin on Dec 31, 2019 in |
The objective of this study was the extraction, recuperation, identification and bioactivity evaluation of the main bioactive compounds present in Chrysactinia mexicana A. Gray, polyphenolic compounds from aerial parts of Chrysactinia mexicana A. Gray were purified using a liquid chromatography column with ambulate XAD-16, first elution was made with distilled water, then ethanol was used to recover the phenolic fraction. These compounds were screened for antibacterial activity using agar diffusion method and antioxidant potential method was determined by ABTS•+, DPPH• and FRAP methods. Most bioactive compounds studied were effective against Klebsiella pneumoniae ATCC 13883, Escherichia coli ATCC 8739 and Salmonella enteric ATCC 7251, the compounds presented moderate inhibition against Staphylococcus aureus CDBB 1005. The polyphenolic profile was determined by HPLC/ESI/MS. The content of total hydrolyzable polyphenols (THP) after purification was 18.17 mgg -1, the content of total condensed total condensed polyphenols (TCP) determined after the extract purification was 18.25 mgg -1. The antioxidant activity of polyphenolic compounds of C. Mexicana (CMG) was determined by the IC50 of ABTS•+– scavenging...
Read More
