Posted by admin on Jul 11, 2017 in |
Plants contain a galaxy of phytoconstituents which accounts for their remedial worth. This plant has been used expansively for its medicinal value all over the world. Different plant parts have been used for its different pharmacological screening, including cancer therapy and leaves can be wrapped to create the “beedi” filled with tobacco which has outsold conventional cigarettes in India. Extraction of plant material with organic solvent and elucidation of pure compounds using a different technique with the different solvent system are an extremely imperative limitation. Elucidation of pentacyclic triterpenoid, ursolic acid from D. melanoxylon and molecular mechanisms has vast chances for the development of enhanced therapy for different diseases, including cancer, and clinical studies. Our extensive intention of this study is to give a general delineate on the thyme D. melanoxylon and its cancer prevention potential, diverse pharmacological action, ethnomedicinal uses, and chemical compounds. We also focus the extraction methodology, elucidation, pharmacokinetic and various clinical trials of ursolic acid chiefly obtained from D....
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Posted by admin on Jul 11, 2017 in |
Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfill specific functions and in some cases; they directly or indirectly influence the extent and rate of drug release and drug absorption. Recent trends towards the use of plant-based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural materials have many advantages over synthetic ones as they are chemically inert, nontoxic, less expensive, biodegradable, improve the shelf life of the product and widely available. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery...
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Posted by admin on Jul 11, 2017 in |
Nature has been a source of medicinal agents since times immemorial. The importance of herbs in the management of human ailments cannot be overemphasized. Different extracts from traditional medicinal plants have been tested to identify the source of the therapeutic effects. As a result, some natural products have been approved as new antibacterial drugs. The objective of this research is to find out the potent antibacterial agents from the selected medicinal plants: Mangifera indica and Osyris lanceolata of Rupandehi, and Palpa districts of Nepal. The Bark and Leaves of the plants Mangifera indica and Osyris lanceolata respectively were subjected to extraction by maceration process using solvent methanol. Screening of antibacterial activity was done by disc diffusion method against the microorganisms Staphylococcus aureus and Escherichia coli at three different concentrations (1 mg/disc, 2 mg/disc, and 4 mg/disc). Both plants showed potent antibacterial activity. Minimum inhibitory concentration (MIC) assay was determined for the two extracts against these bacterias. The concentration 4 mg/disc of M. indica showed maximum activity against both E....
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Posted by admin on Jul 11, 2017 in |
Lantana indica Roxb. (Verbenaceae) is grown as an ornamental plant in tropical and subtropical regions of the world. The plant is used to treat asthma, abdominal disorders, bilious fever, cancer, catarrhal infections, chicken pox, eczema, hypertension, malaria, measles, swelling, rheumatism, tetanus, and ulcers. Phytochemical investigation of a methanolic extract of the leaves led to isolating three new chemical constituents characterized n-heneitriacont-4-en-16β, 17β, 18β-triol (n-heneitriacontenol, 3), 6, 4′- dimethoxy- 7, 3′- dihydroxy flavone- 7- O- β-D-glucopyranoside (lantanaflavone 7-O-β-D-glucoside, 6), urs-12-en-3β-ol-28-oic acid 3β-D-glucopyranosyl-6´-octadecanoate (ursolic acid 3-O-β-D-glucosyl-6′-oleate, 8) along with five known compounds characterized as n- hexadecanyl oleate (1), n-octadecanyl oleate (2), oleanolic acid (4), ursolic acid (5) and oleanolic acid 3-O-β-D-glucopyranoside (7). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical...
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Posted by admin on Jul 11, 2017 in |
Teucrium polium L. is a member of the Lamiaceae family and is represented in the Flora of Syria by two variety: Teucrium polium var. angusti folium and Teucrium polium var. mollissimum. Teucrium polium is a wild-growing flowering plant, found abundantly in Syria, and it is used traditional medicine for it’s diuretic, antipyretic, antispasmodic, tonic, anti-inflammatory, antihypertensive, anorexic, analgesic, antibacterial and antidiabetic effects. Several reports have demonstrated a wide range of beneficial biological and pharmacological activities of the phenylethanoid, phenylpropanoid, and flavonoid components, while the furano neo-clerodane diterpenoids present in germander have been implicated in the in-vivo hepatotoxicity of this botanical. Phytochemical studies of this plant have been carried out. Aerial parts of the plant were extracted with petroleum ether at room temperature, and then extract with methanol in Soxhlet, and finally extract with aqueous methanol at room temperature successively. Fractionation of the methanol extract by column chromatography and purification by crystallization yielded three known flavonoids Cirsimartin 2, Cirsiliol 3, and Apigenin 4. The aqueous methanolic extract yielded one new...
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