Posted by admin on Feb 28, 2015 in |
A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Medicinal plants have been considered as an important therapeutic aid for alleviating ailment of humankind. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. This present investigation was aimed at assessing the hepatoprotective activity of aqueous, ethanol and acetone extract of Sesbania grandiflora leaves against carbon tetrachloride (CCl4) induced liver damage in Albino rats. Silymarin as a standard drug for comparing the activity. The activity was assessed by comparing the biochemical parameters in serum levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase of plant extracts treated group with carbon tetrachloride treated animals. Results showed, ethanolic extract treated group showed highly significant activity (P<0.001), whereas aqueous extract treated group has shown the significant (P<0.01) action but less compared with ethanolic extract, acetone treated group showed moderate action. Plant extracts restore biochemical enzymes and bring down to normal as compared to standard drug silymarin....
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Posted by admin on Feb 28, 2015 in |
Emergence of multidrug-resistant strains of pathogens and adverse effects of antibiotics have rapid lead search for new antimicrobials. Medicinal plants have gained more importance as a source of alternative and effective drugs. Euclea racemosa sub sp. schimperi (DC.) Dandy (Ebenaceae) has many traditional uses against infections and related disorders. The objective of this study was to evaluate the antibacterial potential and identify major phytochemical groups in root extracts of E. racemosa. Root part of the plant was extracted by maceration using methanol, acetone, and chloroform. Extracts were subjected to antibacterial screening against seven bacteria strains: Staphylococcus aureus (ATCC215223), Streptococcus pneumonia (ATCC49619), Streptococcus pyogenes (ATCC19615), Escherichia coli (ATCC259292), Klebsiella pneumonia (ATCC70060), Pseudomonas aeruginosa (ATCC27853), and Salmonella typhi (ATCC1912/R). Well, the diffusion method was used to perform the antibacterial screening. Determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and phytochemical screening was also done on the extracts. Results indicated that the different extracts displayed significant (P<0.05) antibacterial activities and the methanol extract were more active. Flavonoids, glycosides, phenols, saponins,...
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Posted by admin on Feb 28, 2015 in |
Plants are valuable sources of natural products. Despite the availability of different approaches for the discovery of therapeutically, natural products remain as one of the best reservoirs of new structural types. They play a major role in the cure of various diseases from ancient time. Role of plant metabolites to inhibit the growth and activity of pathogenic bacteria is cherished. Research towards the invention of sources of plant metabolites gives sustenance against the problem of development of resistant pathogen. The review presents information about some new sources of phytometabolites against...
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Posted by admin on Feb 1, 2015 in |
Andrographis paniculata Nees is a plant that has been effectively used in traditional Asian medicines for centuries. It’s perceived “blood purifying” property and also for medicinal properties. The present paper deals to study the phytochemical screening of Andrographis paniculata for various medicinally important compounds. In the present investigation, it was found that phenols, alkaloids, tannins, flavonoids are present in leaves, stem, and root of the plant. Saponin is...
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Posted by admin on Feb 1, 2015 in |
The present study was aimed to investigate the cytotoxic activity of different fractions (petroleum ether, ethyl acetate & chloroform) of the rhizome of Alpinia nigra – a plant belonging to the family Zingiberaceae. The rhizome of Alpinia nigra was extracted with organic solvent, and the extracts were fractionated by using three fractions (petroleum ether, ethyl acetate & chloroform). The petroleum ether, ethyl acetate & chloroform soluble fractions of Alpinia nigra were screened for cytotoxic activity using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that petroleum ether, ethyl acetate and chloroform-soluble fractions of Alpinia nigra rhizome possess cytotoxic principles (with LC50 1.245 mg/ml and LC50 2.151 mg/ml and LC50 2.737 mg/ml respectively) comparison with positive control vincristine sulphate (with LC50 0.563 mg/ml). All the extracts of Alpinia nigra showed moderate cytotoxic activities in this experiment. The results of this study are highly...
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