Posted by admin on Feb 1, 2015 in |
Acetaminophen (APAP) is widely used as an analgesic and antipyretic drug. The large dose of APAP results in severe hepatic necrosis due to the oxidative stress. This work evaluates the antioxidant activity of crude water extract of Vetiveria zizanioides roots against a single dose of APAP induced acute hepatotoxicity. Mice were treated with 300 mg/kg of APAP dissolved in saline and fasted for 16 h. N-Acetylcysteine (NAC, 500 mg/kg) was used as a positive control. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) increased significantly 4 h after APAP administration. Oral administration of crude water extract of Vetiveria root at a dose of 0.9 g/kg before or after the oral administration of APAP significantly reduced (P<0.05) the elevated values of serum ALT, AST, ALP and hepatic morphologic changes induced in mice. Antioxidant status, reduced glutathione (GSH), glutathione reductase (GR) and glutathione S-transferase (GST) were reduced significantly (P<0.05) and the lipid peroxidation and the activity of GPx were enhanced significantly in the APAP treated...
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Posted by admin on Feb 1, 2015 in |
The traditional Indian medicine – Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. Wounds are the result of injuries to the skin that disrupt the soft tissue. Wound healing can be defined as a complex dynamic process results in the restoration of anatomic continuity and function. Various plant products have been used in the treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Hence in the current review, a list of the plants used in traditional medicine for the treatment of wounds was screened. It is a beneficial work for researchers to provide many details about the wound healing herbs and development of safe and effective and globally accepted herbal drugs for cuts and...
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Posted by admin on Feb 1, 2015 in |
Peptic Ulcer Disease (PUD) is an inflammation along the mucosal lining of esophagus, stomach or duodenum or anywhere in the gastrointestinal tract. PUD is the most common gastrointestinal disorder in clinical practice because of alteration in lifestyle and food habits. The main symptoms related to PUD are Indigestion, heartburns, burning pain or abdominal pain, nausea, vomiting, constipation, bloating of stomach and abdomen, not feeling of well in both body and mind. In severe cases, symptoms can be dark or black stool (due to bleeding), vomiting blood (look like “coffee-grounds”), Weight loss, and severe pain in the mid to upper abdomen. The most important complications are Hemorrhage, Bleeding, Perforation (a hole through the wall of the stomach), Gastric outlet obstruction, if not treated properly. The drugs like Antacids, H2 Receptor antagonist and Proton pump inhibitors are used for PUD all around world widely to relieve the symptoms by the allopathic medicine side. Many of Medicinal plants are used for their anti-ulcer, anti-secretory & Gastro-protective property by the practitioners of herbal...
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