HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF SESBANIA GRANDIFLORA AGAINST CCl4-INDUCED HEPATIC INJURY IN RATSAbstract
A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Medicinal plants have been considered as an important therapeutic aid for alleviating ailment of humankind. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. This present investigation was aimed at assessing the hepatoprotective activity of aqueous, ethanol and acetone extract of Sesbania grandiflora leaves against carbon tetrachloride (CCl4) induced liver damage in Albino rats. Silymarin as a standard drug for comparing the activity. The activity was assessed by comparing the biochemical parameters in serum levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase of plant extracts treated group with carbon tetrachloride treated animals. Results showed, ethanolic extract treated group showed highly significant activity (P<0.001), whereas aqueous extract treated group has shown the significant (P<0.01) action but less compared with ethanolic extract, acetone treated group showed moderate action. Plant extracts restore biochemical enzymes and bring down to normal as compared to standard drug silymarin. This results shows and confirms the significant protective activity against CCl4 induced hepatotoxicity.
K. Padmalochana* and M. S. D. Rajan
Department of Biochemistry, Sri Akilandeswari Women's College, Wandiwash, Tamil Nadu, India.
31 December 2014
19 January 2015
17 January 2015
01 February 2015