Posted by admin on Mar 31, 2026 in |
The development of anthelmintic resistance and the higher expense of traditional anthelmintic medications caused the Zingiber stigation of medicinal plants as a potential substitute of anthelmintics, utilizing the P. posthuma adult earthworm. The present investigation focuses on the anthelmintic potential of three traditionally used plants of Bangladesh: Zingiber officinale (family: Zingiberaceae), Momordica charantia (family: Cucurbitaceae), and Moringa oleifera (family: Moringaceae) at all tested concentrations (25 mg/ml, 50 mg/ml, and 100 mg/ml), the extracts showed anthelmintic activity. The greatest effect was seen at 100 mg/ml. At higher concentrations, Momordica charantia (Korola) showed the strongest anthelmintic effect among the plants, followed by Zingiber officinale (Ada) and Moringa oleifera (Sajna pata). The traditional use of these plants as natural anthelmintic agents is supported by these...
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Posted by admin on Mar 31, 2026 in |
In recent decades, oral health management has witnessed a paradigm shift by integrating bioactive materials into dental therapeutics. Among these, bioactive glasses (BGs) that were originally developed by Larry Hench in 1969 have garnered significant attention because of their distinctive capacity to bond with bones and soft tissues of the body, while stimulating biological responses that promote healing and regeneration. Bioglass was the first synthetic material that formed a chemical bond with bone. The principal mechanism underlying the bioactivity of BGs lies in their surface reactions in aqueous environments, where they release therapeutic ions like Ca²⁺, Na⁺, PO₄³⁻, and Si⁴⁺, that lead to the formation of a hydroxycarbonate apatite (HCA) layer that mimics natural bone mineral. Furthermore, functionalization of bioactive glasses (BGs) with therapeutic metal ions like Ag⁺, Zn²⁺, Cu²⁺, Sr²⁺ and herbal bioactives has emerged as a promising strategy to enhance their antimicrobial, osteogenic, angiogenic, and anti-inflammatory properties, thereby broadening their applications in dental and ocular implantology, orthopedics, and wound healing. Despite the widespread recognition of its benefits,...
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Posted by admin on Mar 31, 2026 in |
The search for safer alternatives to synthetic neuroactive drugs has increased interest in medicinal spices with potential central nervous system (CNS) activity. Trachyspermum roxburghianum, a traditionally used aromatic spice, remains poorly explored for its neuropharmacological effects. This study evaluated the CNS depressant activity of the methanolic extract of T. roxburghianum seeds in mice. CNS depressant activity was assessed using forced swimming test (FST), tail suspension test (TST), and thiopental sodium-induced sleeping time assay in Swiss albino mice. The extract was administered orally at doses of 50, 100, and 200 mg/kg, while diazepam (1 mg/kg, i.p.) served as the reference standard. Acute oral toxicity was evaluated up to 2000 mg/kg. Qualitative phytochemical screening was performed, and statistical analysis was conducted using paired Student’s t-test (one-tailed). The extract produced a dose-dependent increase in immobility time in both FST and TST. In the thiopental-induced sleeping time test, the extract significantly reduced sleep onset latency and prolonged sleep duration at higher doses. Phytochemical analysis confirmed the presence of flavonoids, terpenoids, saponins, phenolics, tannins,...
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Posted by admin on Mar 31, 2026 in |
Alopecia areata (AA) is a chronic autoimmune disorder leading to non-scarring hair loss and affecting millions worldwide across all age groups. Despite extensive research, the precise molecular mechanisms remain incompletely understood, arising from complex interactions among immune dysregulation, genetic susceptibility, and environmental triggers. Emerging evidence also implicates lifestyle factors, psychological stress, gut microbiome imbalance, and drug exposures in disease onset and progression. This review synthesizes current knowledge on the immunopathogenesis of AA, integrating insights from T-cell mediated autoimmunity, genetic variations, and epigenetic regulation. Advances in diagnostic strategies, including trichoscopy, histopathology, and severity assessment tools, are critically evaluated with attention to their clinical applicability and limitations. Importantly, the therapeutic landscape of AA is rapidly evolving: beyond traditional approaches such as corticosteroids and minoxidil, recent progress in biologics, JAK inhibitors, regenerative strategies including stem cell and exosome-based therapies, nanotechnology, and microneedle-assisted delivery systems is reshaping treatment paradigms. By bridging mechanistic understanding with therapeutic innovation, this review highlights unmet clinical needs, emphasizes opportunities for precision and regenerative medicine, and outlines future directions...
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Posted by admin on Mar 31, 2026 in |
Aromatherapy is a complementary therapeutic approach based on the use of volatile essential oils derived from aromatic medicinal plants. The practice has a long history, originating in ancient medical systems of Egypt, India, China, and Greece, where aromatic plants were employed for therapeutic, cosmetic, and spiritual purposes. In contemporary pharmacognostic research, aromatherapy is recognized for the bioactive potential of essential oils, which are complex mixtures of secondary metabolites such as terpenoids, phenylpropanoids, aldehydes, alcohols, and esters. The mechanisms of action involve olfactory stimulation of the limbic system as well as transdermal absorption, leading to neuropharmacological, autonomic, and systemic effects. Essential oils have demonstrated a range of pharmacological activities including anxiolytic, analgesic, antimicrobial, anti-inflammatory, antioxidant, and sedative effects. Aromatherapy has found applications in the management of stress-related disorders, pain, insomnia, dermatological and respiratory conditions, and as supportive therapy in chronic diseases and palliative care. Medicinal plants frequently employed in aromatherapy include Lavandula angustifolia, Mentha piperita, Eucalyptus globulus, Rosa damascena, and Melaleuca alternifolia. This review consolidates current knowledge on the historical...
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