Posted by admin on May 31, 2026 in |
The present study focuses on the formulation and evaluation of a herbal hair mask using natural ingredients as a safer alternative to synthetic hair care products. The formulation incorporates plant-based components such as flaxseed, fenugreek, aloe vera, and hibiscus, which are known for their nourishing, conditioning, and hair growth–promoting properties. The hair mask was prepared using Carbopol 940 as a gelling agent, glycerin as a humectant, sodium benzoate as a preservative, and triethanolamine for pH adjustment. Two formulations (F1 and F2) were developed and evaluated for various parameters including organoleptic properties, pH, spreadability, stability, and skin irritation. The prepared formulations exhibited a pleasant odor, smooth texture, and appropriate pH suitable for scalp application. Stability studies showed no significant changes in color, odor, texture, or pH under different storage conditions, indicating good stability. The skin irritation test confirmed that the formulation was non-irritant and safe for topical use. Overall, the herbal hair mask demonstrated effective conditioning, moisturizing, and potential anti-dandruff and hair-strengthening properties. The study concludes that the formulated herbal...
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Posted by admin on May 31, 2026 in |
Lung cancer, which is primarily caused by smoking tobacco products, environmental pollutants, and genetic predispositions, continues to be ranked among the biggest contributors of cancer-related death worldwide. Numerous sophisticated cancer treatment methods are inefficient because of metastatic spread and susceptibility to traditional anti-cancer medications. Natural therapeutic compounds developed from plants are presently of considerable curiosity because of their excellent absorption and lack of side effects. Relevant instances involve ginsenosides (from ginseng), curcumin (from Curcuma longa), resveratrol (from grapes), and epigallocatechin gallate (from green tea). These compounds all alter important molecular pathways linked to the growth of lung cancer including NF-κB, STAT3, MAPK, and PI3K/Akt signalling. This article highlights the molecular understandings, experimental evidence, and fresh clinical data that support the utilization of natural products effective adjuvant and chemo preventive therapy for lung...
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Posted by admin on May 31, 2026 in |
The present study aimed to optimize sodium bicarbonate-based effervescent tablets using natural binders through a systematic Design of Experiments (DoE) approach. A Box–Behnken design was employed to evaluate the influence of sodium alginate, sodium bicarbonate, and microcrystalline cellulose (MCC) on formulation parameters. Seven initial formulations (F1–F7) were prepared using different natural binders including fenugreek mucilage, fenugreek powder, acacia, tragacanth, sodium alginate, and guar gum. Based on pre-compression evaluation, sodium alginate (F6) demonstrated superior flowability and compressibility. Further DoE-based optimization using 17 formulations revealed that sodium bicarbonate concentration significantly reduced effervescence time, while sodium alginate enhanced tablet hardness and MCC improved flow characteristics. The optimized formulation (0.10 g sodium alginate, 0.20 g sodium bicarbonate, 1.75 g MCC) exhibited rapid effervescence (10–25 s), acceptable pH (2.88–3.92), adequate hardness (5.35 kg/cm²), and excellent flow properties (Carr’s index 22.5%). ANOVA confirmed model significance (R² > 0.93), supporting the efficacy of natural binders as eco-friendly, safe alternatives to synthetic excipients in effervescent tablet...
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Posted by admin on May 31, 2026 in |
Background: For centuries, Feronia limonia (Wood Apple) and Aegle marmelos (Bael) have served as vital components of traditional medicine in the Indian subcontinent. Both members of the Rutaceae family are prized for their secondary metabolites, particularly flavonoids, which offer potent antioxidant, anti-inflammatory, and cardioprotective benefits. Objective: This review provides a comparative evaluation of the botanical characteristics, phytochemical diversity, and flavonoid concentrations of these two species to determine their relative therapeutic potential. Methods: The study synthesizes existing quantitative data, focusing on extraction efficiencies across various solvents and the biosynthetic pathways Shikimic, Mevalonic, and Malonic acid responsible for their bioactive profiles. Results: Analysis reveals that Aegle marmelos exhibits superior phytochemical diversity and higher flavonoid abundance, with maximum reported values reaching 135.17 mg QE/g in fruit extracts. Comparatively, Feronia limonia shows a maximum of 35.25 mg QCE/g. Discrepancies in content are primarily driven by the plant part utilized, solvent polarity, and fruit maturity stages. Conclusion: While both plants are significant sources of bioactive markers, Aegle marmelos demonstrates a more robust flavonoid profile....
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Posted by admin on May 31, 2026 in |
Inflammation is a critical protective response that involves a complex network of inflammatory modulators, which coordinate the body’s detection, reaction to, and repair of tissue damage or infection. These modulators include cytokines, chemokines, adhesion molecules, lipid mediators, neuroimmune signals, and emerging regulators such as A3 adenosine receptors, formyl peptide receptors, CCN (cellular communication network) proteins, microRNAs, and the Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway. These components work together to initiate and guide immune responses, ensuring effective tissue communication and resolution of inflammation. When functioning properly, inflammation supports healing, but when imbalanced or overactive, it can lead to chronic inflammatory diseases such as arthritis, cardiovascular disorders, autoimmune conditions, and metabolic dysfunction. Understand operate and interact has enabled the development of targeted therapies, including cytokine inhibitors and receptor specific drugs, to restore immune balance. Inflammatory modulators form an interconnected system that determines the intensity, duration, and outcome of inflammation, making them essential targets for improving treatments of chronic inflammatory...
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