Posted by admin on Mar 31, 2026 in |
Inflammation is a protective biological response; however, its chronic manifestation is closely associated with the development of several pathological conditions. The limitations and adverse effects of existing anti-inflammatory drugs necessitate the search for safer and more effective alternatives. In the present study, a series of novel heterocyclic derivatives of 2-thiouracil were designed, synthesized, and evaluated for their in-vitro anti-inflammatory activity. Twelve Schiff base derivatives (6a–6l) were synthesized through sulfonylation, hydrazinyl substitution, and subsequent condensation with various substituted aromatic aldehydes. The synthesized compounds were characterized by melting point determination, elemental analysis, and physicochemical evaluation. In-vitro anti-inflammatory activity was assessed using inhibition of albumin denaturation and human red blood cell (HRBC) membrane stabilization assays, with aspirin serving as the reference standard. All tested compounds exhibited concentration-dependent anti-inflammatory activity. Among them, derivatives 6h and 6b demonstrated the most significant inhibition of protein denaturation and superior membrane stabilization activity, approaching the efficacy of aspirin at higher concentrations. Structure–activity relationship analysis suggested that electron-donating substituents and halogen substitution patterns play a crucial role in...
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Posted by admin on Mar 31, 2026 in |
Raphanus sativus (radish), a member of the Brassicaceae family, is a widely cultivated and consumed root vegetable across the globe. Its nutritional and medicinal significance has been extensively documented through various studies. Traditionally, extracts from both aerial and underground parts of radishes have been employed in folk medicine to manage a range of ailments, including digestive disorders, urinary infections, hepatic inflammation, cardiovascular complications, and ulcers. The therapeutic potential of radish is primarily attributed to its rich composition of bioactive secondary metabolites, such as glucosinolates, polyphenols, flavonoids, and isothiocyanates, which confer antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, and anticancer activities. This review emphasizes the impact of radish extract administration in pathological conditions, including cancer, diabetes, liver dysfunction, and oxidative stress. Additionally, it provides a detailed analysis of the molecular mechanisms by which radish-derived compounds regulate critical drug targets associated with various cancers and metabolic disorders. By modulating signaling pathways, apoptotic proteins, and detoxification enzymes, these bioactive constituents demonstrate considerable potential in preventing and managing chronic diseases, highlighting radish as a promising candidate...
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Posted by admin on Feb 28, 2026 in |
People worldwide have long sought effective ways to alleviate pain, a major symptom of many clinical conditions. To achieve better pain control, there is a continuous need to discover new and effective therapeutic agents. Lime peels (Citrus aurantifolia) have been traditionally used to manage various ailments, including pain and infections, and have also been reported to protect several vital organs. Preliminary phytochemical screening and oral acute toxicity studies were conducted on Citrus aurantifolia peels extract (CAPE). No mortality was recorded during the acute toxicity study; therefore, the LD₅₀ of CAPE was estimated to be greater than 2000 mg/kg. In the acetic acid–induced writhing test, CAPE produced significant (p < 0.001) and non–dose-dependent inhibition of pain, with percentage reductions of 56.9%, 66.5%, and 64.9% at doses of 100, 200, and 400 mg/kg, respectively. In the formalin-induced pain model, CAPE at 200 and 400 mg/kg significantly (p < 0.001) reduced paw-licking time in both the first and second phases. In addition, CAPE significantly increased latency time (area under the curve) and...
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Posted by admin on Feb 28, 2026 in |
The present study aimed to formulate and evaluate a polyherbal capsule using aqueous extracts of Vinca rosea, Curcuma longa, and Dalbergia sissoo. Plant materials were collected, authenticated, dried, and extracted using a traditional aqueous extraction method. Pre-formulation studies were conducted to assess powder flow properties, including bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose. Six formulations (PC1–PC6) were prepared by wet granulation and filled into size “0” hard gelatin capsules using a manual plate method. The capsules were evaluated for organoleptic characteristics, weight variation, disintegration time, moisture content, drug content, in-vitro dissolution, and stability under varying temperature and humidity conditions. Among all formulations, PC1 exhibited superior flow properties, uniform weight, rapid disintegration, and maximum drug release (94.77% at 30 minutes). Stability studies revealed good stability under ambient and moderately elevated temperatures, while degradation occurred at higher temperature and humidity. Overall, the results demonstrate that the developed polyherbal capsule is pharmaceutically acceptable, stable under recommended storage conditions, and holds promise for effective oral herbal...
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Posted by admin on Feb 28, 2026 in |
Cassia fistula is commonly referred to as the golden shower tree is a member of the family Fabaceae. It derives its name due to its catchy yellow flower and lengthy long seed. Aragvada or the plant species called the “disease killer” has been used in the past to treat respiratory tract infections and congestion in the upper tract. In Ayurvedic medicine it has been applied in the treatment of Vata, Pitha and Kappa. The numerous components of the plant such as pods, pulp, leaves, bark, and flowers are applied in treating various diseases such as skin diseases, diabetes, constipation, infections, and inflammation. This page aims at compiling a summary of the literature available on the botany, ethnomedicinal potential, phytochemistry, pharmacological effects, safety, and formulation development of Cassia fistula. The compounds possess strong antioxidant, anti-inflammatory, antimicrobial, anti-diabetic, hepatoprotective, anti-tumor, antitussive and laxative properties. This thorough review of the literature offers a base to the further pharmacological research as it summarizes the current information on the therapeutic usefulness of Cassia...
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