Posted by admin on Jun 30, 2025 in |
Chocolate is the most loving food among the people. It is the easiest form to chew and absorb for every individual. This research deals into the Innovative application of herbal chocolates, a delightful fusion of traditional enjoyment and holistic well-being. The blending of herbal ingredients with the luxurious texture of chocolate has given rise to a new category of confectionery that not only satisfies sweet cravings but also offers potential health advantages. The essential target of this study was to formulate and evaluate nutritious chocolate and nutritional supplement containing anti arthritis property. Chocolate is a range of products derived from cocoa (cocoa) mixed with fat and finely powered coconut sugar to produce a solid confectionery. Sesame is the herbal drug which has several medicinal properties, like anti arthritis property, antioxidant property, from the prevention of rheumatoid arthritis. Sesame was used to improve blood pressure and act as anti aging agent. Thus, we have to formulate the chocolate with aqueous extract of sesame. Chocolate is a sophisticated and infinitely adaptable...
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Posted by admin on Jun 30, 2025 in |
Diabetes mellitus is a globally prevalent chronic metabolic disorder characterized by hyperglycemia due to insufficient insulin production or impaired insulin utilization. It is associated with various acute and chronic complications, including neuropathy, nephropathy, retinopathy, and cardiovascular diseases. With rising incidence rates, especially in urban regions of developing countries like India, diabetes poses a major public health challenge. While conventional treatments involve insulin therapy and oral hypoglycemics, herbal medicine offers a promising complementary approach. This study reviews the antidiabetic potential of several medicinal plants, such as Momordica charantia, Aloe barbadensis, Catharanthus roseus, Glycyrrhiza glabra, Syzygium cumini, Curcuma longa, Stevia rebaudiana, Senna auriculata, Cinnamomum cassia, and Taraxacum officinale. Each plant is explored for its phytoconstituents, such as alkaloids, flavonoids, glycosides, and terpenoids, which exhibit hypoglycemic, antioxidant, anti-inflammatory, and insulin-mimetic properties. Experimental evidence from in-vivo and in-vitro studies supports their efficacy in managing blood glucose levels, improving insulin sensitivity, and protecting pancreatic β-cells. This compilation emphasizes the therapeutic potential of herbal remedies as safe and cost-effective adjuncts in diabetes management and encourages...
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Posted by admin on Jun 30, 2025 in |
Sickle cell disease (SCD) treatment and management remain a challenging puzzle, especially among developing Nations. We evaluated catechin’s sickling-suppressive properties using in-vitro and bioinformatics approaches in human sickle erythrocytes. Sickling was maximally induced (76%) using 2% sodium metabisulfite (SMS) at 3h. Addition of catechin prevented the sickling by SMS at 1mM (81.19%) and reversed the same at 1mM (84.63%), with IC50 values of 1.026µM and 1.103µM, respectively. Based on functional chemistry, catechin alters the functional groups of certain notable compounds within erythrocytes, favouring its anti-sickling effects, as indicated by the observed bends and shifts. From GC-MS and LC-MS analyses, it was observed that catechin treatment favours fatty acid alkyl monoesters (FAMEs) production with concomitant shutting down effects on selenocompound metabolism. Pathway enrichment and topology analyses revealed activation of fatty acid biosynthesis, linoleic acid metabolism and steroid hormone biosynthesis pathways upon catechin treatment. Thus, sickling-suppressive effects of catechin could potentially be associated with modulation of oxygenated and deoxygenated haemoglobin via alteration of human sickle erythrocytes’ functional chemistry and metabolic pathways...
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Posted by admin on Jun 30, 2025 in |
To perform phytochemical screening, estimate total phenolics and total flavonoid content of hydro alcoholic extract of dried leaves of Portulaca grandiflora Hook. The shade- dried leaves of P. grandiflora (100 g) were extracted exhaustively by Soxhlet with hydro- alcohol. The conc. hydro-alcoholic extract were further studied to quantitative determination, GC-MS and HPTLC to identify and characterize the chemical compound present in the crude extract. The phenolic content present in hydro-alcoholic leaf extract was found to be 1.57µg/ml (µg of Gallic acid/mg of extract) and flavonoid content was found to be 2.73µg/ml (µg of Rutin/mg of extract). Phytochemical analysis of hydroalcoholic extract showed presence of major classes of phytochemicals. High performance – thin layer chromatography results revealed the mobile phase of ethyl acetate: formic acid: glacial acetic acid: water (10:0.5:0.5:1.3), the fluorescent band under (254 nmand366 nm) at Rf 0.21 was identified, and the marker chemical rutin was measured. Gas chromatography – mass spectroscopy results showed the presence of 27 phytoconstituents including phenolic acids, ketones, flavonoids, carbohydrates, and hydrocarbons. The...
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Posted by admin on Jun 30, 2025 in |
This study evaluated the antibacterial activity of eight commercially available toothpaste samples (P1–P8) and a standard antibiotic control (Tetracycline) against three oral bacterial isolates (C2, C3, C4) and Escherichia coli using the well diffusion method. Zones of inhibition were measured to assess antimicrobial efficacy. Among all samples, P1 demonstrated the highest activity, with inhibition zones surpassing those of the antibiotic control for several strains. P8 exhibited consistent activity across all bacteria, while P2 was selectively effective against C3. In contrast, P4, P6, and P7 showed no activity against E. coli. Notably, E. coli resistance to several formulations underscores the need for rigorous post– brushing rinsing to minimize potential impacts on gut microbiota. The results affirm that antibacterial efficacy varies widely among commercial toothpaste brands, likely due to differences in formulation and active components. This study highlights the superior antibacterial action of certain commercial toothpastes compared to antibiotics and also underscores the importance of product–specific evaluation for effective oral health...
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