Posted by admin on May 31, 2022 in |
Using the plant as a source of medicine is one of the major campaigns in the field of alternative therapy. This study was conducted to investigate the antimicrobial activity of Leptadenia hastate root. The root of this plant was collected, dried, and ground. The powder was subjected to extraction by cold maceration using water and methanol. The in-vitro antimicrobial activity of the extract was tested against four strains of bacteria: Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, Bacillus cereus and one fungus Candida albicans using the agar diffusion method. DMSO was used as a negative control; Ciprofloxacin was used as a positive control for bacteria and fluconazole as a positive control for fungi. The agar dilution method determined the minimum inhibitory concentration (MIC) of crude extract. The phytochemical analysis was conducted to determine the secondary metabolites. The antimicrobial activities show that methanol extract of Leptadenia hastate was only sensitive against Bacillus cereus and Candida albicans out of five organisms tested, while aqueous extract does not show activity against any organism...
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Posted by admin on May 31, 2021 in |
Objective: Stem Bark, Root, and fruit of Ziziphus oenoplia (Rhamnaceae) has been used in traditional health systems to treat diabetes and many more disorders in southern Asia as India, Sri Lanka, and Burma. However, the anti-oxidant and hypoglycemic potential of the fruit of this valuable plant is not scientifically validated till date. The aim of the present study is to evaluate in vitro free radical scavenging and hypoglycemic effect of ethanol extracts and solvent fractions of Ziziphus oenoplia fruit. Methods: The ethanol extracts and three solvent fractions of Ziziphus oenoplia fruit were evaluated at different concentration (20- 640 µg/ml) for free radical scavenging activity by using in-vitro DPPH method and different concentration (25-800 µg/ml) for hypo-glycemic potentials by using α – glucosidase and α-amylase enzymes (intestinal enzymes which slow the digestion of carbohydrates and delay glucose absorption) inhibitory activity. Results: The outcome of present study indicates that maximum anti-oxidant activity was produced by ethanol crude extract (87.66±1.54% Inhibition at 640 μg/mL) with IC50 value 2.72±0.62 followed by chloroform fraction...
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Posted by admin on May 31, 2021 in |
Plants are naturally gifted for the synthesis of medicinal compounds & extraction is the first crucial step in the preparation of plant formulations. The extraction and characterization of active compounds from medicinal plants have resulted in the discovery of new drugs with high therapeutic value. The new recent extraction techniques with shortened extraction time, reduced solvent consumption, and increased pollution prevention concern and with special care for thermolabile constituents. In this article, the principle behind the operation of various extraction methods, factors influencing method performance, research progress, strength and weakness of different extraction approaches are discussed. The modern techniques for extraction of herbal plant secondary metabolites include Solid-phase micro-extraction, Supercritical-fluid extraction, Pressurized liquid extraction, Accelerated Solvent extraction, High-pressure solvent extraction, Membrane Extraction, The Cold finger method Stir-bar sportive extraction, Ultrasonic extraction, Acid-base extractions, Solid-phase extraction, Microwave-assisted extraction (MAE), Supercritical fluid extraction (SCFE), Pressurized solvent extraction...
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Posted by admin on May 31, 2021 in |
The methanolic rhizome extract of Pseudodrynaria coronans (MEPC) was assessed for its preliminary phytochemical constituents, anti-nociceptive and anti-inflammatory activity. Acute toxicity of the extracts was tested following the OECD – 425 guidelines and after giving MEPC at the dose of 2000 mg/kgb.w indicating that the LD50 is higher than the given dose. Two doses 200 and 400 mg/kg bw. were selected for all the experiments. Hot plate and Tail immersion methods showed that the extract was statistically significant (p<0.05 and p<0.01). Different concentrations of the MEPC showed significant inhibition of protein denaturation and membrane stabilization. Also, the MEPC exhibited significant inhibition of carrageenan-induced paw oedema (p<0.01) and cotton pellet-induced granuloma (p<0.05 & p<0.01) inflammatory responses in the...
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Posted by admin on May 31, 2021 in |
Mentha (also known as mint, isa genus of plants in the family Labiatae /Lamiaceae). The genus Mentha L. is distributed all over the world and can be found in many environments. Mint is a popular and well-known herb growing all over the world and includes many varieties and hybrids. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, cosmetics, and alternative or complementary therapy, mainly to treat rheumatic pains, aching head, and digestive disorders. Aerial parts of the plant are refrigerant, stomachic, carminative, stimulant, and diuretic. They possess antispasmodic and emmenagogue properties and are also given to stop vomiting and to treat jaundice. The oil is a valuable anti-neuralgic 66. The peppermint has been used in the pastin herbal medicine dating back to the ancient Egyptian, Greek, and Roman times Murray...
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