Posted by admin on May 31, 2019 in |
The improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and concluded with the plausible mechanism of hydrogen bond donor/acceptor felicitator to the surface active molecule by the hydrogen bonding with the surfactant polar head group to increase the fluidity of the system. Through this unique mechanism, the co-surfactant expands the area of existence of microemulsion. The system allows the topical drug with the stable as well as a flexible system with higher drug entrapment. The systems aligned toward the liquid crystal phase than the liquid phase, which makes the system more convenient for the delivery...
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Posted by admin on May 31, 2019 in |
The liver is an amazingly complex organ which virtually affects every physiological process of the body. The liver is the largest glandular organ in the body and has more function than any other organs. Hepatic disorders which stem from a stressful lifestyle, inappropriate eating habits, and lack of exercise have become one of the major causes of morbidity and mortality in human being. The acute hepatic symptoms may be cured by some general prevention such as avoidance of constipation and balance between intake quantity of protein and disaccharides in normal food. An alternative and progressively increasing adaptation is the use of herbal extracts. Many of the plant-based drugs show an effective response to managing the hepatotoxicity and secondary symptoms of liver damage. While, the models used for conventional hepatotoxicity evaluation are still outdated, in the present review we have attempted to provide updated information of the molecular pathogenesis and aspects for the role of herbal pharmacotherapy in the alleviation of hepatic ailments. Furthermore, we have attempted to summarize the...
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Posted by admin on May 2, 2018 in |
The present research aimed at scrutinizing the role of Mahua Oil (MO) as a suppository base which can enhance the release of drug in the site of administration. Three formulations were designed with erythromycin as the drug utilizing; F1 (MO and Beeswax in the ratio of 3:1), F2 (MO and PEG 6000 in the ratio of 1:1), and F3 (cocoa butter – 100%) as the base material. The suppositories were prepared using pour molding method after suitable calibration of molds. All the formulations were characterized in terms of breaking strength, disintegration time, drug content, in-vitro dissolution, and accelerated stability studies. The MO containing formulations displayed a good breaking strength, optimized disintegration time, and higher drug content as compared to the cocoa butter formulation. The optimized formulation F2 represented the optimized release of 81.35% over the range of 1 h. A little difference in drug content (1.78%), breaking strength (0.2 Kg/cm2), and disintegrating time (0.6 min) was observed in the accelerated stability study. The study concluded that MO has a...
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Posted by admin on May 2, 2018 in |
Anatomical characters and thin layer chromatographic fingerprint of root, root-bark and leaf of Agnimanthaḥ (Premna serratifolia L.), an important drug used in Ayurvedic system of medicine has been studied in detail to identify the original drug from the...
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Posted by admin on May 2, 2018 in |
The drug is obtained from the dried fruit of Nyctanthes arbor-tristis of family Oleaceae. It is also called Coral Jasmine, Parijat, and Harsingar, etc. To confirm the veracity of the claim above, the anticonvulsant effect of the ethanolic extract has been evaluated. In this investigation, the rats were pretreated with different dose of Nyctanthes arbor-tristis ethanolic extract (100, 200 mg/kg) for 14th days and then, they were subjected to maximal electroshock-seizures, the dose of 100 and 200 mg/kg significantly reduced the duration of hind limb extension, and both the doses were statistically found to be equipotent. The reference, standard, Phenytoin (30 mg/kg) provided complete protection. Thus, the present study revealed the anticonvulsant effect of Nyctanthes arbor-tristis against maximal electroshock-induced convulsion in the...
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