Posted by admin on May 31, 2020 in |
Treatment based on traditional medicine is very popular in the developing world due to inexpensive properties. There is a growing interest in herbal medicine. Curcumin a hydrophobic poly-phenol is derived from turmeric, the rhizome of the herb Curcuma longa L. Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Curcumin has an outstanding safety profile and a number of pleiotropic actions with potential for neuroprotective efficacy, including anti-inflammatory, antioxidant, and anti-protein-aggregate activities. Because of its pleiotropic actions on the central nervous system, including preferential binding to amyloid proteins, Curcumin is being touted as a promising treatment for age-related brain diseases. This review article aims at gathering information predominantly on neurodegenerative...
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Posted by admin on May 31, 2020 in |
Salacia chinensisis, commonly known as Saptarangi in the Hindi family of Hippocrateaceae, it is a woody climbing shrub found in Africa, Vietnam, and Thailand. A large number of biologically active compounds like salacinol, kotalanol, neokotalanol, neosalacinol, salasol, and mangiferin are isolated from S. chinensis. Traditionally, the plant is used in the treatment of diabetes, but there are few studies that demonstrate its use as anti-inflammatory, nephroprotective, anticancer, and treatment of cardiac disorders. The present study involves extraction, isolation, structural elucidation, and prediction of antioxidant activity from the roots of S. chinensis. The roots were extracted with water and methanol by using a hot extraction method. The methanol extract was fractionated with ethyl acetate. The antioxidant activity of different extracts was determined by 1, 1-diphenyl-2- picryl- hydrazyl (DPPH) method. The highest antioxidant activity was found in ethyl acetate extract, followed by methanol extract and water extract. Ethyl acetate extract showed maximum antioxidant activity, so the extract was used for the isolation of antioxidant compounds by column chromatography. The compound was...
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Posted by admin on May 31, 2019 in |
The role of surfactants is very critical in the development of pharmaceutical formulations. The diverse applications in different delivery systems have been highlighted in different reports of formulation development for various conventional and advanced delivery systems. The relevancy of critical micelle concentration and HLB value for the section of surfactants for different drug delivery systems was rationalized with suitable examples. The present attempt is focused on the compilation of all the important aspects of surfactants with a broad discussion on the drug delivery implications. The regulatory status of different investigational surfactants has been criticized relevantly with a compilation of FDA approved surfactants. The safety aspects of newly developed surfactants must be ensured before their incorporation in therapeutic dosage forms. The properties of different categories of surfactants were discussed with special emphasis on their physicochemical properties. The compiled information will make a firm base for the selection of surfactants for conventional and advanced drug delivery systems. Precise information on surfactant toxicity was also included to give a check to the...
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Posted by admin on May 31, 2019 in |
The current study was aimed to investigate the analgesic activity of the methanolic extract of Amaranthus spinosus leaf (Family: Amaranthaceae). The analgesic activity was assessed with this extract for their peripheral and central anti-nociceptive potentials using three standard test methods, for instance, acetic acid induced writhing, hot plate and tail immersion methods in Swiss albino mice, at the doses of 200 and 400 mg/kg body weight. In acetic acid induced writhing method, methanolic extract of Amaranthus spinosus leaf (200 and 400 mg/kg) showed significant peripheral analgesic activity with writhing inhibition of 58.02% and 63.2% respectively whereas the standard drug diclofenac-Na (25 mg/kg) showed 73.88% writhing inhibition. In the hot plate test, methanolic extract of the leaf (200 and 400 mg/kg body weight) showed 55.09%, and 66.22% central nociception inhibition of thermal stimulus respectively, where the standard drug morphine (5 mg/kg) displayed 50.35% nociception inhibition. In the tail immersion test, maximum 68.19% and 73.91% nociception inhibition of thermal stimulus was exhibited with methanol extract of the leaf (200 and 400...
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Posted by admin on May 31, 2019 in |
Amaranthus spinosus, belongs to Amaranthaceae family, is an annual or perennial herb grows annually; native to tropical America and found throughout India as a weed in cultivated as well as fallow lands. Though the whole plant is used as a laxative, the roots are regarded as highly specific for colitis, and it is also used as antipyretic, febrifuge, diuretic. Other than its culinary value, it is utilized in the treatment of bronchitis, digestible, appetizer, biliousness, haematinic, galactagogue, stomachic, flatulence, nausea, anorexia, blood diseases, leucorrhoea, burning sensation, leprosy, and piles. This study aimed to investigate the anti-nociceptive activity of the ethanol extract of the root of Amaranthus spinosus Linn. The anti-nociceptive activity was investigated for its peripheral and central pharmacological action using acetic acid-induced writhing, hot plate, and tail immersion methods in Swiss albino mice at the doses of 200 and 400 mg/kg body weight. Ethanol extract of the root (200 and 400 mg/kg) showed the most significant anti-nociceptive activity in acetic acid induced writhing method with writhing inhibition of...
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