Posted by admin on May 31, 2021 in |
Plants are naturally gifted for the synthesis of medicinal compounds & extraction is the first crucial step in the preparation of plant formulations. The extraction and characterization of active compounds from medicinal plants have resulted in the discovery of new drugs with high therapeutic value. The new recent extraction techniques with shortened extraction time, reduced solvent consumption, and increased pollution prevention concern and with special care for thermolabile constituents. In this article, the principle behind the operation of various extraction methods, factors influencing method performance, research progress, strength and weakness of different extraction approaches are discussed. The modern techniques for extraction of herbal plant secondary metabolites include Solid-phase micro-extraction, Supercritical-fluid extraction, Pressurized liquid extraction, Accelerated Solvent extraction, High-pressure solvent extraction, Membrane Extraction, The Cold finger method Stir-bar sportive extraction, Ultrasonic extraction, Acid-base extractions, Solid-phase extraction, Microwave-assisted extraction (MAE), Supercritical fluid extraction (SCFE), Pressurized solvent extraction...
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Posted by admin on May 31, 2021 in |
The methanolic rhizome extract of Pseudodrynaria coronans (MEPC) was assessed for its preliminary phytochemical constituents, anti-nociceptive and anti-inflammatory activity. Acute toxicity of the extracts was tested following the OECD – 425 guidelines and after giving MEPC at the dose of 2000 mg/kgb.w indicating that the LD50 is higher than the given dose. Two doses 200 and 400 mg/kg bw. were selected for all the experiments. Hot plate and Tail immersion methods showed that the extract was statistically significant (p<0.05 and p<0.01). Different concentrations of the MEPC showed significant inhibition of protein denaturation and membrane stabilization. Also, the MEPC exhibited significant inhibition of carrageenan-induced paw oedema (p<0.01) and cotton pellet-induced granuloma (p<0.05 & p<0.01) inflammatory responses in the...
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Posted by admin on May 31, 2021 in |
Mentha (also known as mint, isa genus of plants in the family Labiatae /Lamiaceae). The genus Mentha L. is distributed all over the world and can be found in many environments. Mint is a popular and well-known herb growing all over the world and includes many varieties and hybrids. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, cosmetics, and alternative or complementary therapy, mainly to treat rheumatic pains, aching head, and digestive disorders. Aerial parts of the plant are refrigerant, stomachic, carminative, stimulant, and diuretic. They possess antispasmodic and emmenagogue properties and are also given to stop vomiting and to treat jaundice. The oil is a valuable anti-neuralgic 66. The peppermint has been used in the pastin herbal medicine dating back to the ancient Egyptian, Greek, and Roman times Murray...
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Posted by admin on May 31, 2021 in |
Objective: To investigate the Pharmacognosy as well as the Antioxidant, Anti-inflammatory potential of the Katha powder. Methods: The Coarsely dried chips of Acacia catechu heartwood were treated with 10% hydro-alcoholic solution to obtain Katha as the final product. The powdered Katha was standardized via pharmacognostic parameters. This Kathapower is showing good solubility in hot water, having astringent in the taste. The powder microscopy of the Katha powder is to be demonstrated fragments of acicular crystals, fibers and bordered pitted vessels. Katha powder antioxidant potential is to be accessed by using the DPPH assay and NO Scavenging assay by using ascorbic acid as a standard drug. Further, the Katha powder is to be subjected for the assessment of its anti-inflammatory potential by use of Heat-induced hemolysis as well as the Hypotonicity-induced hemolysis approach by the use of aspirin or diclofenac sodium as a standard drug. Results: Microscopical investigations were showed that Katha showing the presence of fragments of acicular crystals, fibers, and bordered pitted vessels. In-vitro study shows that the...
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Posted by admin on May 31, 2021 in |
The spread of infectious diseases in the world is a major challenge for health institutions and pharmaceutical industries. The current trends of multi-drug resistance to the available synthetic drugs or antibiotics among emerging and re-emerging bacterial pathogens lead to serious risks. It is therefore necessary to search for new antimicrobial agents that are better, cheaper and without side effects for treating these infectious diseases, especially in developing countries. In this study, phytochemical composition and antimicrobial activities of aqueous and methanol extracts of stem-barks of Mangifera indica were investigated. Standard methods were employed to screen for the presence of phytochemicals. Agar well diffusion method was used to determine the antimicrobial effects of aqueous and methanolic extracts of M. indica stem-bark against selected bacterial (Shigella sp, Staphylococcus sp, Escherichia coli, Vibrio sp) and fungi (Penicillium sp, Yeast, Mould) isolates. Phytochemical results showed the presence of active pharmacological components such as tannins, saponins, glycoside, flavonoid, terpenoid, alkaloids, and steroid. Methanol extract demonstrated the highest activity of bacterial (Staphylococcus sp with 15.4 ±...
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