Posted by admin on Feb 28, 2025 in |
Natural plant extracts have gained interest in cancer research due to their potential therapeutic properties. This study investigates the in-vitro cytotoxic effects and phytochemical composition of Mammea africana stem bark and Calophyllum inophyllum leaves methanol extracts against H460 lung cancer cells using the MTT assay, with 5-Fluorouracil (5FU) as a standard control. Phytochemical screening revealed that M. africana had high terpenoid content and moderate levels of flavonoids, tannins, and phenolics, while C. inophyllum had higher flavonoid and phenolic content, moderate saponins and terpenoids, and lower tannins and alkaloids. The extraction yields were 12.5% w/w for M. africana and 9.8% w/w for C. inophyllum. Cytotoxicity analysis demonstrated that M. africana exhibited strong cytotoxic effects, with an IC₅₀ value of 2.60 µg/mL, comparable to 5-Fluorouracil (IC₅₀ = 2.71 µg/mL), while C. inophyllum showed moderate cytotoxic activity (IC₅₀ = 30.00 µg/mL). The cytotoxic effects were dose-dependent, with M. africana achieving 97.47% cytotoxicity at 100 µg/mL, whereas C. inophyllum reached 85.4% at the same concentration. The findings suggest that the potent cytotoxic effects of Mammea africana could be attributed to its high terpenoid and tannin content, whereas the moderate activity of C. inophyllum may be linked...
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Posted by admin on Feb 28, 2025 in |
Cancer is a dangerous global disease and causes a heavy economic burden in low-income countries. Traditional medicinal plants play an important role in the research and development of cancer treatment drugs. Twenty-four traditional Vietnamese herbs were evaluated for their cytotoxic activities against nine cancer cell lines including HepG2, A549, MCF7, HT-29, HeLa, RD, LNCaP, HL-60 and NTERA-2. Cytotoxic activity was assessed following Monks’ protocol (1991) by measuring total cellular protein content using sulforhodamine B (SRB) staining. The 70% ethanol extract of eight medicinal herbs including Phyllanthus urinaria L. (TD.MD1), Solanum trilobatum L. (TD.MD2), Angelica sinensis (Oliv.) Diels (TD.MD3), Xanthium strumarium L. (TD.MD11), Scutellaria baicalensis Georgi (TD.MD15), Platycodon grandiflorus (Jacq.) A.D.C. (TD.MD17), Lycopodium clavatum L. (TD.MD20) and Ophiopogon japonicus (Thunb.) Ker Gawl. (TD.MD21) showed cytotoxic activity against HepG2, A549, MCF7, HT-29, HeLa, RD, LNCaP, HL-60 cell lines with IC50 values ranging from 18.60 to 93.84 µg/mL. The hexane, ethyl acetate, n-butanol, water extract residues of the 70% ethanol extracts demonstrated cytotoxic activities against NTERA-2 cell line with IC50 values of...
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Posted by admin on Feb 28, 2025 in |
Ayurveda, the science of life, has a rich history in India and has been utilized for millennia to address various health issues. Ayurveda is deeply established in the application of mixtures of various herbs and medications to address numerous health issue. It includes a vast array of remedies, two of which are fermented: Asava and Arishta. These alcohol-based medicines are created by fermenting herbal liquids or decoctions with the addition of sugars. Asava and arista are considered unique Ayurvedic dosage forms due to their unlimited shelf life. Naturally produced alcohol in these preparations amplifies the medicinal and therapeutic properties of the treatments. Ayurvedic formulations like Asava and Arishta are highly regarded due to their unique characteristics that render them more beneficial compared to other preparations. This study provides an overview of the latest available information regarding Arishta and...
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Posted by admin on Feb 28, 2025 in |
The fruit, native to Central America, is known for its unique appearance and rich nutritional content. This profile includes an examination of the plant’s macroscopic and microscopic features of fruit anatomy. A significant focus is placed on the phytochemical constituents of Canistel, which include alkaloids, flavonoids, tannins, and terpenoids. These compounds associated with various biological activities. The bioactive substances contribute to the plant’s antioxidant property suggesting its therapeutic potential in traditional medicine. Also the plant’s role in managing conditions like diabetes, hypertension, and digestive disorders has been documented in traditional medicine. The pharmacognostic profile also includes the plant’s pharmacological properties, which support its use in the development of natural health products. The canistel is egg-shaped fruit and sweet, dense pulp Microscopically, the plant’s cellular structures, such as Parenchyma cells, Vascular Tissues, Fibres and vascular bundles, This detailed anatomical study helps in ensuring the authenticity and quality of the plant material used in medicinal applications. The plant’s medicinal uses also support its potential therapeutic value, as it has been utilized...
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Posted by admin on Feb 28, 2025 in |
Tinospora cordifolia (Giloy), has been utilized across Ancient Indian and Ayurvedic medication for centuries due to its significant pharmacological properties. This comprehensive review explores the botanical, chemical, and therapeutic aspects of T. cordifolia, highlighting its widespread distribution, detailed plant description, and various vernacular names. The plant’s cultivation preferences, climate and soil requirements, and propagation methods are examined. Additionally, the review delves into the plant’s medicinal potential, particularly its antiviral and immunomodulatory properties, which acquired prominence during COVID-19. Active compounds such as glycosides, steroids, diterpenoid lactones, and alkaloids contribute to its pharmacological efficacy. T. cordifolia enhances the host immune system, promotes skin health, and offers anti-aging benefits. While generally safe, precautions for certain conditions like diabetes and pregnancy are advised. This review underscores T. cordifolia’s role in modern herbal medicine and its potential for future pharmacological...
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