Posted by admin on Oct 1, 2014 in |
Introduction: Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type-II. Different factors increase insulin resistance, but FFA is the most common factor to increase insulin resistance. Aims and Objectives: Most of the obese person (80%) is DM Type-II, but all obese are not diabetic, why? To study the FFA level in obese without DM Type-II verses obese with DM Type-II subjects. Materials and Methods: Subjects were taken from OPD & IPD, Department of Medicine, SRMS, IMS Bareilly (U.P.) India, of both sexes, coming from reasonable distances around Bareilly city. They were from the lower and middle class of rural area having moderate physical activities, with vegetarian as well as non-vegetarian dietary habits and were obese as per new Asian BMI guidelines and have symptoms of diabetes. Subjects were not on any drug treatment before taken blood sample. Serum FFA level estimated by ELISA...
Read More
Posted by admin on Oct 1, 2014 in |
In the present study the anti-inflammatory, analgesic activity and mechanistic pathway of Centratherum anthelminticum (Willd.) Kuntze (CA), Cissus quadrangularis Linn. (CQ) and Kigelia pinnata DC (KP) was tested in rats using carrageenan induced paw edema method. The central analgesic activity was assessed by radiant heat method, hot plate method, and tail immersion method. The peripheral analgesic action was estimated using acetic acid induced writhing test. To establish the mechanism of action of the hydroalcoholic extract, membrane stabilization, antioxidant, antihistaminic, muscle strength, and coordination activity were performed. In anti-inflammatory activity; CA, CQ, and KP showed maximum inhibition of 77%, 70% and 50% respectively. In analgesic activity, CA and CQ treated animals responded propitiously to both central and peripheral analgesia, but KP treated animals demonstrated significant activity only for peripheral analgesia. This can be attributed to membrane stabilization, anti-oxidant, and antihistaminic potential. All the three test drugs have shown both anti-inflammatory activity and analgesic activity with varying potency and mechanisms of...
Read More
Posted by admin on Oct 1, 2014 in |
An ethnomedicinal survey was carried out during August 2008 to October 2008 among tribal medicinal practitioners of the Murong tribes. Various Murong tribal practitioners practiced in their localities for treating different kinds of disease of Ramgarh Upazila, Khagrachari districts of Chittagong Hill Tracts Region in Bangladesh. We observed to use 40 plants species belonging to 29 families in the various treatment of disease. This diversity only adds to the uniqueness of the traditional medicinal practices and opens up scientific possibilities of discovering different drugs from different medicinal plants to treat any given ailment. These tribal medicinal plants were mostly used for the treatment of constipation, cough, fever, diarrhoea, dysentery, diuretic, diabetes, eczema, itches, jaundice, skin disease, vomiting, wound, joint pain and worm. The plants were collected and identified botanically along with their scientific name, local name, family name, habit, parts used and medicinal uses. This detailed information will be helpful for the pharmacognosist, botanist and pharmacologist for the collection and identification of the plant for their research...
Read More
Posted by admin on Oct 1, 2014 in |
Thevetia peruviana is found distributed throughout tropical parts of India. Their leaves are used as cardiotonic and diuretic. Flowers of plant Thevetia peruviana were reported to possess good medicinal value in the traditional system of medicine; the present investigation deals with macroscopic, microscopic and preliminary phytochemical investigation of flowers of Thevetia peruviana which includes pharmacognostical parameters, physiochemical parameters like ash values, extractive values, and moisture content. The main aim of the present investigation is to study the macro, microscopic and some other pharmacognostic characters and physicochemical standards of flowers of Thevetia peruviana Pers. which could be used to prepare a monograph for the proper identification of the plants....
Read More
Posted by admin on Oct 1, 2014 in |
Oxidative stress has been implicated in various pathological diseases like neurodegenerative disorders, stroke, cancer, inflammation, atherosclerosis, etc., which upshots when the production of reactive oxygen species overwhelms the antioxidant defense mechanism. Nowadays, development of drugs with antioxidant potential gained utmost importance therapeutically to treat many pathological diseases. Plant-derived anti-oxidants were proven to be more effective than synthetic antioxidants. With this as focus, the present study investigated the antioxidant potential of punicalagin (PG) in an in-vitro system of goat liver slices imperiled to oxidative stress. Precision cut goat liver slices are used as an in-vitro model for the evaluation of anti-oxidant activity because it crafts in-vivo tissue environment and helps in curtailing the use of intact animals. In our study, hydrogen peroxide is used as an oxidant to create oxidative stress to the liver slices. Hydrogen peroxide treated liver slices showed a significant decrease in both enzymatic and non-enzymatic antioxidant levels as compared with normal liver slices. PG treated liver slices showed significant improvement in both enzymatic and non-enzymatic antioxidant...
Read More