Posted by admin on Dec 31, 2023 in |
Background: Diabetes mellitus, or simply diabetes, is a set of endocrine ailments characterized by persistently elevated blood sugar levels. Diabetes is caused by either the pancreas not making enough insulin or the body\’s cells becoming resistant to the hormone\’s effects. Thirst, polyuria, weight loss, and impaired eyesight are common indications of Diabetes. Combining herbal therapy seems to be beneficial in the treatment of type 2 diabetes and related issues. Aim: The goal of the current research was to formulate a polyherbal anti-diabetic formulation using Withania coagulans, Emblica officinalis, and Trigonella foenum-graecum. Method: Material like pulverized powder of Trigonella foenum-graecum Linn, Withania coagulans Dunal, and Emblica officinalis were used in the present study for phytochemical screening, tablet punching, and in-vitro study along with the flow properties of Polyherbal granules. Polyherbal tablets were used in the in-vitro antioxidant DPPH experiment and the in-vitro anti-diabetic effect was examined using alpha-amylase enzyme inhibitory activity. Result: The flow properties of the developed Polyherbal granules were remarkable. In an in-vitro investigation, polyherbal tablets were examined...
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Posted by admin on Jan 31, 2023 in |
Sapindus emarginatus Vahl. is extensively used in Indian traditional and folklore medicines to cure various human ailments. The preliminary phytochemical screening of the leaves revealed the presence of saponins, terpenoids, tannins, acids, flavonoids, cardiac glycosides, and sugars. Saponin applications were observed due to various biological, medicinal, and pharmaceutical actions. Several other uses for Sapindus have also been reported, such as making arrows from wood and decorative objects from seeds. The presence of saponin glycosides in the plant parts produces many beneficial pharmacological actions. These Sapindus drugs contain different active constituents, which various methods of extraction and separation methods can isolate. The choice of extraction procedure depends on the nature of the plant material and the components to be isolated. Maceration extraction, Soxhlet extraction, and microwave-assisted extractions give the most effective extraction of saponins from Sapindus species. Hence, this present review article provides detailed information about the different isolation procedures of saponin...
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Posted by admin on Jan 31, 2023 in |
The expansion of research on finding herbal sources for producing new effective and safe medicinal herbal remedies is an urgent pharmacy task. One of the ways to increase the amount of herbal medicinal preparations is a broad study of the pharmacological action of non-pharmacopoeial medicinal plants used in folk medicine. One of these plants is Black root officinalis (Cynoglossum officinale), which grows wild in the European part of Russia, Siberia, Central Asia, and the Caucasus, including North Ossetia, but does not form significant thickets. Today Cynoglossum officinale is used mainly in folk medicine as an anti-inflammatory, analgesic, sedative, and expectorant. When applied externally, Cynoglossum exhibits antipruritic properties and is capable of tissue regeneration. Therefore, the pharmacognostic study for further research on pharmacological effects on the human body is quite...
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Posted by admin on Jan 31, 2022 in |
The solid drug dosage form, especially the tablet formulations, are made with natural polymer- microcrystalline cellulose (MCC) fibers with many other inorganic agents exclusively to achieve the physical form of the tablet than to enhance the drug efficacy or lowering dosage or frequency of administration. Direct compression is effected directly or after following the procedure of wet granulation. If we explore various digestible fibers from vegetable sources and extract the fibers using the same process as that of MCC, the drug delivery and additional effect of the base can be achieved simultaneously. The review article discusses various ingredients used in tablet formulation and their possible limitations and side effects. Further, the article also elaborates on various physiological, genetic, and tissue-related thrush-holds modifications in the human body viz., tachyphylaxis, tolerance, and other changes towards various drugs, and how such modifications pose an additional challenge in the treatment. Such challenges always compel us to look for newer drug molecules where a simple change in the delivery mechanism armamentarium of the tablet...
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Posted by admin on Jan 31, 2022 in |
Blighia sapida a tropical evergreen plant with a dense crown, is commonly called ackee apple. Traditionally, the stem backs and leaves of the plant are used in the treatment of high fever, strokes, malaria, headache and some eye ailments. This study examined the antiplasmodial activity of Blighia sapida leaf extracts in comparison with the standard antimalarial drug Artemether-Lumefantrine combination, with a view to determining the changes in the parasitemia level in mice infected with Plasmodium berghei. The results showed a significant decrease in parasitemia level over six days period for mice treated with Artemether-Lumefantrine, ethanolic, and aqueous leaf extracts of B. sapida, whereas the controls showed a continuous increase. The parasitemia level was significantly reduced (P<0.05) in mice treated with 6.0mg/kg body weight of Artemether-Lumefantrine with 88% suppression; those treated with the ethanolic leaf extract at 50mg/kg and 30mg/kg body weight had parasitemia suppressed by 59% and 43.67% respectively. Parasitaemia count in mice treated with 50mg/kg and 30mg/kg body weight of aqueous leaf extract of B. sapida was suppressed...
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