Posted by admin on Dec 31, 2024 in |
Context: Obsessive-Compulsive disorder (OCD) is one of the most common neurological illness worldwide. Marble burying behavior in murine models is a unique and precise model for the assessment of anti-OCD like action of the tested drug. Lagenaria siceraria (Molina) Standley (LS), popularly known as “bottle gourd”, is a potent indigenous vegetable plant with high therapeutic value. Objective: The aim of this study was to evaluate the anti-OCD (anti-compulsive) effects of the methanolic extract of LS fruits (MLSF) and the phytosterol rich Chloroform fraction of methanolic extract of LS fruits (CFMLS) using the marble-burying test in mice. Materials and Methods: The screening of anti-OCD action was carried out on Swiss Albino mice. Moreover LC-MS/MS analysis was carried out for the isolation and identification of the bioactive phytoconstituents responsible for the anti-OCD like effect of CFMLS. Results and Conclusions: MLSF and CFMLS, at doses of 100, 200, and 400 mg/kg, p.o., decreased the total number of buried marbles in dose dependent manner. At dose of 400 mg/ kg, CFMLS exhibited the...
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Posted by admin on Dec 31, 2024 in |
This study explores the phytochemical composition and antimicrobial potential of Euphorbia hirta, a medicinal plant known for its therapeutic properties. Phytochemical screening of its aerial parts revealed the presence of bioactive compounds such as alkaloids, flavonoids, saponins, terpenoids, steroids, and sterols. Methanol extracts were evaluated for antimicrobial activity using the agar cup-plate diffusion method, demonstrating significant inhibitory effects against Escherichia coli. These findings highlight the plant’s natural antimicrobial properties, suggesting its potential as a valuable resource for addressing bacterial infections. Our findings suggest that Euphorbia hirta holds promise as a natural antimicrobial agent and Isolated Flavonoid from E. hirta Extracts shows maximum antimicrobial activity as compared with the whole extract of Euphorbia hirta. The study underscores the importance of Euphorbia hirta in the development of herbal-based therapeutics. Future research will focus on isolating and characterizing the active compounds responsible for its antimicrobial effects. Understanding the mechanisms of action of these compounds could lead to the creation of novel, plant-derived antibacterial agents, offering an alternative to conventional antibiotics in combating...
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Posted by admin on Dec 31, 2024 in |
Herbal insecticidal formulations using two indigenous plants were developed keeping in view disadvantages of the use of synthetic products and to embolden eco-friendly approach. Plants selected were screened for insecticidal and antifeedant activities. Oil in water emulsion-based creams and wettable powder were formulated. Creams were evaluated for different parameters like appearance, pH, spreadability, texture analysis, extrudability, homogeneity, skin irritation, short term stability study and estimation of phytoconstituents while powder granules for appearance, pH, wettability, persistent foaming, suspensibility, spontaneity of dispersion, particle size analysis and flow property. The formulations were found to be stable during stability study according to ICH guidelines. Results indicate that prepared herbal formulations can effectively be used as safe and user convenient...
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Posted by admin on Dec 31, 2024 in |
Dalbergia sissoo Roxb. is a extensively used as timber growing throughout India. Its heartwood is found to be used in several ailments. The same is employed as an anti-inflammatory agent by various traditional healers and its use is also mentioned in the number of ancient texts. The influence of the drug on carrageenan induced rat paw edema was studied. The drug was found effective by different perspectives of examinations proving its anti-inflammatory...
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Posted by admin on Dec 31, 2024 in |
Quercetin, a flavonoid with diverse health benefits, has anti-allergic, anti-inflammatory, antiviral, and anti-cancer properties. Found in fruits and vegetables like onions, apples, and berries, Quercetin has shown potential in combating cancer growth, chronic inflammation, and oxidative stress. Various studies suggest Quercetin may effectively manage type 2 diabetes and its complications, offering a safer alternative to conventional treatments. Conventional treatments for type 2 diabetes often involve costly medications with adverse side effects. In contrast, Quercetin offers a natural, cost-effective solution with minimal risks. It has been identified as a potential anti-diabetic agent due to its ability to modulate glucose metabolism, improve insulin sensitivity, and mitigate oxidative stress. This review aims to summarize the current evidence on the anti-diabetic effects of quercetin, its underlying mechanisms, and its potential as a therapeutic agent for the management of type 2 diabetes. Overall, quercetin appears to be a promising anti-diabetic agent, warranting further investigation for its potential use in the prevention and treatment of type 2...
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