Posted by admin on Jan 31, 2022 in |
The solid drug dosage form, especially the tablet formulations, are made with natural polymer- microcrystalline cellulose (MCC) fibers with many other inorganic agents exclusively to achieve the physical form of the tablet than to enhance the drug efficacy or lowering dosage or frequency of administration. Direct compression is effected directly or after following the procedure of wet granulation. If we explore various digestible fibers from vegetable sources and extract the fibers using the same process as that of MCC, the drug delivery and additional effect of the base can be achieved simultaneously. The review article discusses various ingredients used in tablet formulation and their possible limitations and side effects. Further, the article also elaborates on various physiological, genetic, and tissue-related thrush-holds modifications in the human body viz., tachyphylaxis, tolerance, and other changes towards various drugs, and how such modifications pose an additional challenge in the treatment. Such challenges always compel us to look for newer drug molecules where a simple change in the delivery mechanism armamentarium of the tablet...
Read More
Posted by admin on Jan 31, 2022 in |
Blighia sapida a tropical evergreen plant with a dense crown, is commonly called ackee apple. Traditionally, the stem backs and leaves of the plant are used in the treatment of high fever, strokes, malaria, headache and some eye ailments. This study examined the antiplasmodial activity of Blighia sapida leaf extracts in comparison with the standard antimalarial drug Artemether-Lumefantrine combination, with a view to determining the changes in the parasitemia level in mice infected with Plasmodium berghei. The results showed a significant decrease in parasitemia level over six days period for mice treated with Artemether-Lumefantrine, ethanolic, and aqueous leaf extracts of B. sapida, whereas the controls showed a continuous increase. The parasitemia level was significantly reduced (P<0.05) in mice treated with 6.0mg/kg body weight of Artemether-Lumefantrine with 88% suppression; those treated with the ethanolic leaf extract at 50mg/kg and 30mg/kg body weight had parasitemia suppressed by 59% and 43.67% respectively. Parasitaemia count in mice treated with 50mg/kg and 30mg/kg body weight of aqueous leaf extract of B. sapida was suppressed...
Read More
Posted by admin on Jan 31, 2022 in |
Natural herb Ajwain, Trachyspermum ammi (L.) Sprague is an annual herbaceous plant belonging to the highly valued medicinally important family, Apiaceae; the essential oil from the fruits are the phenols, mainly thymol, and some carvacrol. The Indian Pharmacopoeia requires Ajowan oil to contain not less than 40 percent thymol. The remainder of the oil is called ‘thymene’. Thymene, which constitutes c. 45 percent of the oil, has the following composition: p-cymene, 50-55; gterpinene, 30-35; a- and ß-pinenes, 4-5; and dipentene, 4-6%. Presence of minute ‘amounts of camphene, myrcene, and D3-carene is also reported. Kapoor is a tree of many faces as it is a giant, stately forest tree native of the wet forests of tropical and subtropical regions of Asia. The species Camphora refer to camphor, an important chemical constituent present in the oil found in tree tissues. The botanical name is derived from the Greek language. It is derived from the word ‘kinnamomon’ which means spice. This herb is recorded in Sanskrit also. This is also used by...
Read More
Posted by admin on Jan 31, 2021 in |
Propolis is a natural material that can be found in bee honey. It has many medical uses due to its antibacterial activity. This study aimed to estimate the antibacterial efficacy of three propolis extracts using three different solvents (Ethanol, Methanol, and Ethyl Acetate). We experienced the three extracts on four different strains of bacteria (Klebsiella pneumonia, E. coli, Pseudomonas aruginosa & Staphylococcus aureus). The results indicated that all the studied propolis extractions do not have any efficacy on Klebsiella neither on E. coli. The methanolic extract has the greatest effect on Staphylo-coccus aureus as well as on Pseudomonas aruginosa in contrast to ethanolic and ethyl acetate extracts, which has no efficacy on any of the studied bacterial...
Read More
Posted by admin on Jan 31, 2021 in |
All information about the herbal drug, including all its organoleptic characters, phytoconstituents, pharmacological actions, and its standardization in respect to various parameters, is required before developing an herbal drug formulation. Butea monosperma (Lam.) is commonly known as the Flame of the forest, belongs to the family Fabaceae. Commonly Butea monosperma is used as tonic, astringent, aphrodisiac, and diuretics. We are doing this work because it was thought worthwhile to explore this most functional plant based on this standardization parameter. The objective of the work is to study pharmacognostic and physicochemical characteristics of the root of Butea monosperma Fresh and dried root; root powder was studied for its morphology, microscopy, physicochemical, phytochemical characteristics, and other WHO-recommended methods for standardization. The root of Butea monosperma was observed to be brown in color and irregular in shape with a rough surface. The root has a characteristic odour and faint taste. Microscopy revealed the presence of cork cells; Medullary rays distinct parenchymatous cells narrow in the xylem region and wider in the phloem...
Read More