EXPLORING AYURVEDA AND TRADITIONAL MEDICINES: EFFICACY OF POLYHERBAL ANTIDIABETIC TABLETS AND THEIR ANTIOXIDANT PROPERTIES

Background: Diabetes mellitus, or simply diabetes, is a set of endocrine ailments characterized by persistently elevated blood sugar levels. Diabetes is caused by either the pancreas not making enough insulin or the body\’s cells becoming resistant to the hormone\’s effects. Thirst, polyuria, weight loss, and impaired eyesight are common indications of Diabetes. Combining herbal therapy seems to be beneficial in the treatment of type 2 diabetes and related issues. Aim: The goal of the current research was to formulate a polyherbal anti-diabetic formulation using Withania coagulans, Emblica officinalis, and Trigonella foenum-graecum. Method: Material like pulverized powder of Trigonella foenum-graecum Linn, Withania coagulans Dunal, and Emblica officinalis were used in the present study for phytochemical screening, tablet punching, and in-vitro study along with the flow properties of Polyherbal granules. Polyherbal tablets were used in the in-vitro antioxidant DPPH experiment and the in-vitro anti-diabetic effect was examined using alpha-amylase enzyme inhibitory activity. Result: The flow properties of the developed Polyherbal granules were remarkable. In an in-vitro investigation, polyherbal tablets were examined for anti-diabetic effectiveness. The polyherbal formulation was high in polyphenols and flavonoids. When compared to acarbose, it likewise displayed great antioxidant properties as well as significant -glucosidase and -amylase activities. The Polyherbal Granules had a peak at 278 nm, indicating the presence of flavonoids and phenols, according to the UV-Vis spectra. More research using an in-vivo model is needed, however, to examine the role of free radicals and anti-diabetic effects in the treatment of type 2 diabetes.