Posted by admin on Jan 31, 2025 in |
GSTC is a polyherbal formulation comprising Commiphora mukul, Salacia reticulata, Terminalia arjuna, and Curcuma longa, developed to address atherosclerosis through multi-targeted mechanisms. Its phytochemical constituents include guggulsterones, mangiferin, arjunolic acid, and curcuminoids, each offering diverse pharmacological actions. Guggulsterones from C. mukul are recognized for their hypolipidemic and anti-inflammatory effects, while mangiferin and salacinol from S. reticulata provide antidiabetic, anti-obesity, and cholesterol-lowering benefits. T. arjuna contributes arjunolic acid and phytosterols, known for cardioprotective, antioxidant, and anti-inflammatory properties. Curcuminoids and ar-turmerone from C. longa exhibit potent antioxidant, anti-inflammatory, and hypolipidemic actions. Pharmacological studies demonstrate GSTC’s efficacy in reducing cholesterol, triglycerides, LDL, and VLDL levels while elevating HDL in high-fat diet models. Its mechanisms include inhibition of lipid peroxidation, regulation of HMG-CoA reductase, and modulation of inflammatory pathways such as NF-κB and COX-2. The formulation also prevents fatty liver accumulation and enhances lipid metabolism, GSTC exhibits significant antioxidant activity and platelet peroxidation inhibition. GSTC’s unique composition and pharmacological profile suggest its potential as a safe and effective therapeutic agent for managing atherosclerosis...
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Posted by admin on Jan 31, 2025 in |
Adhatoda vasica (L.) Nees is a well-known medicinal plant in both Ayurvedic and Unani traditions, widely used for treating various health issues, especially respiratory tract disorders. Over the past two decades, numerous scientific studies have highlighted the oxytocic and abortifacient properties of vasicine, an alkaloid derived from the plant. This paper provides an overview of the most recent research on its phytochemical and pharmacological properties. The review emphasizes the diverse range of phytochemical compounds extracted from the Adhatoda vasica plant and it possesses various activities like anti allergic, anti-tubercular, immunomodulatory, anti-asthmatic, bronchodilator, hepatoprotective, antiviral, anti-inflammatory, anti-fungal, anthelmintic, thrombolytic activities. Various phytochemicals like alkaloids, flavonoids, tannins, etc. were obtained from Adhatoda vasica (A. vasica). The active constituent of the plant is vasicine, l-vasicinone, deoxyvasicine, maiontone, vasicinolone and vasicinol etc. This review consists of updated information on the phyto-constituents isolated from A. vasica and their potential role in the treatment of various ailments traditionally and...
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Posted by admin on Dec 31, 2024 in |
The Thar Desert is a vital repository of medicinal trees that play a significant role in the traditional healthcare practices of local communities. This study was conducted in the Sardarshahar tehsil of Churu district, located in the Thar Desert, to document and analyse the uses of medicinal tree species. Data were gathered through a review of relevant literature and field observations. A total of 20 medicinal tree species from 11 families were identified and analysed for their medicinal applications. Among these, 65% trees were used for their bark, 40% each for leaves, root, and seed, 15% for flower, 10% for stem and 5% for gum, fruit/pod and whole plant by the local people. The findings highlight the extensive traditional knowledge associated with the utilization of these trees and underscore their significance in local healthcare practices. This study serves as a baseline for understanding the medicinal flora of the region, emphasizing the need for conservation efforts to protect these valuable natural resources and preserve indigenous knowledge for future...
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Posted by admin on Dec 31, 2024 in |
Plant-based anticancer drugs have played a crucial role in cancer treatment for many years. According to Ayurveda, various cancer phases are intractable, chronic inflammatory disorders. Natural products have high potential for the prevention and treatment of different cancers. More importantly, anticancer naturopathics have been modified to gain first-line, second line, and third-line targeting in tumor tissues. This review will explore 25 plant-based anticancer drugs, their mechanisms of action, marketed products, side effects, and relevant...
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Posted by admin on Dec 31, 2024 in |
The Achanakmar-Amarkantak Biosphere Reserve is a remarkable biodiversity hotspot situated in the heart of India, straddling the states of Madhya Pradesh and Chhattisgarh. Geographically, this biosphere reserve is located in the Deccan Peninsula and the Central Highland Plains region, capturing a diverse array of flora and fauna. The region is renowned for its innumerable natural vegetation and zoological wonders, which have long captivated the attention of biologists and researchers. Beyond the northern Himalayan valleys, this biosphere reserve represents the second-largest expanse of biodiversity in India, with a wealth of species that have been documented in various Vedic and botanical literature. Interestingly, many of the plants and herbs found in this region possess valuable ethno-medicinal and pharmacological properties, some of which are yet to be fully explored and understood. The local communities and indigenous tribes have a deep, symbiotic relationship with the biosphere, utilizing its natural resources for food, fodder, medicine, and economic sustenance. This review delves into the biodiversity, biogeographical features, and the ethnobotanical significance of the Achanakmar-Amarkantak Biosphere...
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