Posted by admin on Sep 2, 2015 in |
Plants have been used for centuries as a remedy for human diseases because they contain phytochemical components of therapeutic values. Hexane, ethyl acetate and ethanolic extract of Premna latifolia were investigated for phytochemical constituent and antioxidant activity. The phytochemical constituent was investigated using standard chemical methods. Further, the study was extended by analyzing the antioxidant potential using DPPH method. The results showed that ethanolic extract showed a significant number of phytoconstituents and better radical scavenging activity at the concentration of 75...
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Posted by admin on Sep 2, 2015 in |
Dandruff is a common disorder affecting the scalp. Malassezia furfur, the lipophilic dimorphic yeast-like fungus is the main causative agent of dandruff. In recent years plant-based products are widely used as the therapeutic weapon to cure human disorders. The plant Garcinia indica (Kokam) belonging to family Clusiaceae native to India is one of such plants which has shown many therapeutic uses. One part of the present study shows that the optimum conditions for the growth of Malassezia furfur were on sabouraud’s dextrose liquid medium supplemented with corn oil at 30 °C with pH ranging between 8 and 9 and the other part emphasizes on the screening of M. furfur against fractions separated from fruit rinds of G. indica. Out of three screened fractions (Methanolic extract, water fraction and ethyl acetate fraction), ethyl acetate fraction showed a good zone of inhibition 18.2 ± 0.3 mm and 22.6 ± 1.22 mm at 75 and 100% concentration...
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Posted by admin on Sep 2, 2015 in |
Objective: a Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhizic acid (GA) is chemically pentacyclic triterpenoid which possesses powerful anti-inflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepared using heat seal technique using 23 factorial design allowing for independent variables like penetration enhancers, formulation matrix and rate controlling membranes. The GA patches were evaluated for in-vitro and ex-vivo drug permeation through cellophane membrane and rat skin respectively. The biological evaluation regarding skin irritation study and the anti-inflammatory effect of GA patches on rat paw edema were tested and compared with standard Aceclofenac patch. Result: The reservoir-type patch of F4 formulation, containing 5% menthol as a permeation enhancer, 42% ethanol, 2% carpool 934 gel bases (50 g) with 0.5% piperine provided an improved sustained release of phytopharmaceuticals through transdermal administration. The anti-inflammatory action F4 formulation showed no skin irritation with significant inhibition of rat paw...
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Posted by admin on Sep 2, 2015 in |
The present study was to evaluate the physicochemical changes that take place in vasarishta during the manufacturing of the arishtams (hydro-alcohol class of drug of Ayurveda). The manufacturing process of the Arishtams usually takes 21 -30 days. The time period of the entire study was 21 days. Batch fermentation was done for a period of 14 days after which the fermentation process was inhibited using methods recommended in Ayurvedic literature and as per the company’s standard operating procedure. The arishtam was analysed for its physicochemical parameters periodically at an interval of 24 h. The parameters chosen for the physicochemical characterisation of the fermentation process were pH, Temperature, Specific gravity, Brix value, Sugar content, Alcohol content, Free amino acid content and Tannin content. The pH was found to vary between 4.30 and 5.57. The temperature was found to vary randomly between 25 ºC and 29 ºC throughout the period. The specific gravity was found to decrease drastically up to the 14th day followed by a gradual increase up to the...
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Posted by admin on Sep 2, 2015 in |
Bauhinia Purpurea was commonly known as a purple orchid tree, belonging to the family Caesalpinaceae, sparingly grown in India. The use of natural products as medicinal agents presumably predates the earliest recorded history. It is a species of flowering plant is used in several traditional medicine system to cure various diseases. This plant has been known to possess antibacterial, antidiabetic, analgesic, anti-inflammatory, anti-diarrheal, anticancerous, nephroprotective and thyroid hormone regulating activity. A wide range of active chemical compound including 5,6-Dihydroxy-7-methoxyflavone 6-O-β-D xylopyrano- Side, bis[3,4-dihydroxy-6-methoxy-7,8-furano-5,6-monomethylalloxy]-5-C-5-biflavonyl and (4-hydroxy-7-methyl 3-C-α-L-rhamnopyranosy) – 5 – C – 5 -(4-hydroxy-7-methyl) – 3 – C – α-D-glucopyranosyl], biflavonoid, bibenzyls, dibenzoxepins, mixture of phytol fatty esters, lutein, β-sitosterol, isoquercitrin and astragalin etc. The present review discusses medicinal properties, Biological activity, Phytochemistry and Pharmacology of Bauhinia...
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