Posted by admin on Sep 30, 2025 in |
The human gut microbiota harbours numerous microbiota which includes archaea, fungi, viruses and bacteria. A balanced and healthy gut microbiota is essential for maintaining optimal physiological functions and thus the overall health and well-being. The state of a balanced gut microbiome is known as eubiosis, while dysbiosis is condition where an imbalances or disruptions in the gut microbiota, occurs. Dysbiosis has been associated with a range of diseases including gastrointestinal disorders, metabolic syndrome, neurological disorders chronic inflammation etc. The term probiotics refers to live microorganisms that, when ingested in adequate amounts, confer health benefits. The emergence of using probiotics therapeutically to repopulate the gut with eubiotic microorganisms and improve health introduces many new concepts. On the contrary, prebiotics are food components that promote the growth or metabolism of beneficial microorganisms (e.g., bacteria & fungi). They can alter the gut microbiome makeup. Both probiotics and prebiotics have been effective in a variety of diseases. Nevertheless, concerns over standardization and safety dictate rigorous assessment of strains/formulations. New innovative therapeutic strategies are...
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Posted by admin on Sep 30, 2025 in |
Moringa oleifera is the plant most frequently used by diabetic patients in Bamako (Mali) for the management of their diabetes. The present study aimed to determine the pharmacognostic parameters of the leaves of Moringa oleifera harvested in Mali. The pharmacognostic study consisted of determining the botanical characteristics (organoleptic features and microscopic elements), physicochemical parameters (water and ash contents), and chemical constituents according to methods described in the European Pharmacopoeia. The powder of leaves of M. oleifera was green in color, with a semi-coarse texture, an uncharacteristic odor, and an insipid flavor. Micrograph revealed the presence of anomocytic stomata, calcium crystals, single-celled covering hairs and spiral vessels. The water content is greater than 10%. The contents of insoluble ashes in 10% diluted HCl were less than 1%. Phytochemical screening revealed the presence of polyphenols (flavonoids and tannins), saponins, sterols and triterpenes. Pharmacognostic parameter determined on this study can help in the efficient utilization of this medicinal...
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Posted by admin on Sep 30, 2025 in |
`Yastimadhuvati’ is a popular Ayurvedic formulation prescribed in cough, cold, respiratory diseases and chronic fever. The proposed study is aimed at developing physico-chemical parameters and estimating the contents of glycyrrhetinic acid and piperine in the formulation. Pills were prepared according to the Vaidyaka chikitsasar. The pills were subjected to pharmacognostical and phytochemical screening and evaluated for the standards visually, weight variation, friability and hardness tests. Further glycyrrhetinic acid was quantified by colorimetric method. Also a simultaneous HPTLC method was developed for quantification of glycyrrhetinic acid and piperine. The pills showed microscopical features like sclereids, crystal fibres, vittae, epidermis with subepidermis and oil glands. The acid insoluble ash was found to be 0.5 ± 0.61, Water soluble extractive value was higher than the alcohol soluble extractive value. The pills contained higher amounts of phenolics. The content of glycyrrhetinic acid was found to be almost same (0.4% w/w) when estimated by colorimetric and HPTLC methods. Piperine content was found to be 3.5%w/w using the same HPTLC method. The quality parameters developed...
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Posted by admin on Sep 30, 2025 in |
Medicinal plants remain an integral part of global healthcare systems, with nearly 70–80% of the population in developing countries relying on herbal remedies. Capparis divaricata Lam. (family: Capparaceae), a traditionally valued plant, has long been used as both food and medicine by various ethnic groups and practitioners of Ayurveda and Unani medicine. This review highlights the taxonomy, morphology, phytochemical profile, and pharmacological potential of C. divaricata. s. Pharmacological investigations report a wide spectrum of activities, including analgesic, antipyretic, antioxidant, anticancer, diuretic, CNS depressant, and antitubercular effects. Notably, ethanol and aqueous extracts showed potent inhibition of Mycobacterium tuberculosis, while chloroform and ethyl acetate extracts exhibited significant cytotoxicity against HeLa cancer cells. Collectively, available evidence suggests that C. divaricata is a promising medicinal resource with potential applications in drug discovery. However, detailed phytochemical isolation, mechanism-based studies, and clinical validation are essential to establish its safety and efficacy for future pharmaceutical...
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Posted by admin on Sep 30, 2025 in |
Bryophytes are known for chemically diverse group of non-vascular plants, and secondary metabolite of these plants, particularly in their lipophilic fractions yet remain unexplored in most of the plants. The present study deals with the analysis and investigation of the non-polar chemical composition of hexane extract of Bryum capillare using Thin Layer Chromatography (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) technologies. TLC revealed the different bands of presence of non-polar compounds and GC-MS analysis identified a range of hydrocarbons, fatty acids esters, terpenoids including diterpenes, triterpenes. These findings contribute to the scant phytochemical literature available on mosses and suggest the existence of non-polar bioactive compounds that may have therapeutic...
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