Posted by admin on Feb 28, 2019 in |
Withania somnifera is a traditional indigenous plant having numerous medicinal values. With renewed interest, the present study was undertaken to determine its new potential therapeutic benefit. We aimed to evaluate the effect of methanolic extract of Withania somnifera leaves in L-methionine induced hyperhomocysteinemia in rats. Wistar rats (250-300 gm) were divided into 5 groups (n=6/group): Group I= Normal control (vehicle, 1% CMC); Group II= Hyperhomocysteinemic rats (L-methionine, 1 gm/kg, p.o.); Group III= Methanolic extract of Withania somnifera (200 mg/kg, p.o.); Group IV= Methanolic extract of Withania somnifera (400 mg/kg, p.o.); Group V= Folic acid (1 gm/kg, p.o.). All the rats except normal control group were treated with L-methionine for the induction of hyperhomocysteinemia. Animals of Group III-V were subjected to the respective treatment for 30 days. On completion of the study, serum homocysteine, cholesterol, triglyceride, LDL, VLDL, and HDL level were determined. Administration of L-methionine significantly increased the serum homocysteine, cholesterol, triglyceride, LDL, VLDL levels while decreased HDL level compared to normal control. Methanolic extract of Withania somnifera (200...
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Posted by admin on Feb 28, 2019 in |
The present study was undertaken to provide the rationale for the use of Terminalia bellirica as an anti-inflammatory agent using carrageenan-induced inflammation and antiulcer agent using ethanol-acid induced gastric mucosal injury model in the Swiss albino rats. The anti-inflammatory activity of the extract was evaluated using carrageenan (1% w/v) induced inflammation model at doses of 50, 120 and 300 mg/kg, p.o while using ibuprofen (20 mg/kg, p.o) as the standard drug. On the other hand, the antiulcer activity of methanolic extract of T. bellirica leaves at the doses of 100, 250 and 500 mg/kg, p.o. were examined against ethanol-acid induced gastric mucosal injury in the Swiss albino rats – keeping omeprazole (20 mg/kg, p.o.) as the reference. The rats were dissected, and their stomachs were macroscopically examined to identify hemorrhagic lesions in the glandular mucosa. Further, the histopathological changes of paws and stomachs were analyzed. T. bellirica significantly (P<0.01) decreased carrageenan-induced paw edema; it exhibited a reduction of 50.00%, 55.88% and 61.76% at doses of 50, 120 and 300 mg/kg respectively. The methanolic extract also...
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Posted by admin on Feb 28, 2019 in |
The plant Soymida febrifuga is called as Mamsaroyini in Sanskrit. It is an important medicinal plant belongs to family Meliaceae. This plant has got the traditional and ethnomedicinal significance. This is commonly used for Anti-inflammatory and also for joint pain, for cattle it is used for easy placental expulsion in the tribal areas of North-eastern Karnataka. Keeping its medicinal significance in a view, the present study is focused on phytochemical and pharmacognostic studies, and results show the presence of secondary metabolites such as phenols, flavonoids, triterpenes, lactones, tannins, saponins, alkaloids which in turn may be the responsible for its medicinal...
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Posted by admin on Feb 28, 2019 in |
Diabetes mellitus (DM), both type I and type II, is a common metabolic disorder worldwide. It is characterized by hyperglycemia, lipid, and protein metabolism abnormalities, and accompanied by several clinical complications including retinopathy, neuropathy, and nephropathy. Many traditional herbs have been used for the treatment of DM. In the present review, we showed a list of these herbs describing their growth area, anti-diabetic properties, their active constituent, and mechanism of action. From the review, the anti-diabetic activity of herbs is largely attributed to the presence of polyphenols, flavonoids, terpenoids, and coumarins. Also, this review strongly suggests these herbs as a natural and safe alternative treatment to the regularly used chemical anti-diabetic...
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Posted by admin on Feb 5, 2018 in |
The objective of this research is to evaluate the preliminary phytochemical analysis and antibacterial activity from the medicinal plant of Hugonia mystax of Dindigul district, Tamil Nadu. The leaves of plant Hugonia mystax was subjected to Soxhlet extraction process by using solvent ethanol. Preliminary phytochemical analysis of ethanol extract of Hugonia mystax leaves showed the presence of carbohydrate, flavonoids, phenolic groups, saponins, steroids, tannins, and terpenoids. In-vitro antibacterial activity was performed by the plate hole diffusion method in MH agar medium. The bacteria used for the antibacterial study were Bacillus lichenformis (NCIM 2468), Brevibacterium luteum (ATCC 15830), Escherichia coli (ATCC 11775), Flavobacterium devorans (NCIM 2581), Klebsiella pneumonia (ATCC 11229), Micrococcus flavus (NCIM 2984), Micrococcus luteus (NCIM 1207). Ethanol extract of Hugonia mystax exhibited the best result of the maximum zone of inhibition observed against gram-positive as well as gram-negative bacteria. The anti-bacterial activity revealed the medicinal potential of Hugonia mystax to develop a drug against human...
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