Posted by admin on Jan 31, 2025 in |
Paclitaxel, a potent anticancer agent, was first isolated from the bark of Taxus brevifolia in the 1960s and has since become a cornerstone in chemotherapy. Its anticancer efficacy stems from its ability to stabilize microtubules, preventing their disassembly, which inhibits mitosis and ultimately induces apoptosis in cancer cells. This mechanism of action makes paclitaxel particularly effective against a variety of cancers, including ovarian, breast, and non-small cell lung cancer. Despite its clinical success, the isolation of paclitaxel from the Taxus species is limited by low yields and environmental sustainability concerns, prompting the development of alternative synthetic routes. The synthesis of paclitaxel has posed significant challenges due to its complex structure, particularly the C-ring, which is pivotal for its biological activity. Over the years, total syntheses have been achieved using both chemical and semi-synthetic approaches, with the latter being more commercially viable. One notable method involves converting baccatin III, a compound found in Taxus, into paclitaxel via chemical modifications. Stability issues are another hurdle for paclitaxel’s therapeutic use, as its...
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Posted by admin on Jan 31, 2025 in |
Pharmacognostic study is important in laying down diagnostic parameters for standardization and authentication of plant materials in their fresh, dried or powdered state. Pharmacognostic study serves as a tool to identify adulterants and prevent substitution. Authentic plant material serves as raw material for herbal drug industry and local markets where people prefer folk medicine. Impatiens walleriana (Family – Balsaminaceae) is a folk medicine. Pharmacognostic studies on Impatiens walleriana species are not reported and our findings shall contribute to proper authentication of the plant material and also resolve the complexity associated with species having same common names as other species in the same genera. In the present study various parameters organoleptic, chemomicroscopic, macroscopic and microscopic characteristics have been studied in addition to fluorescence, physical and photochemical analysis. This study therefore generates resourceful data helping to identify Impatiens walleriana and guide researchers to explore therapeutic worthiness of this...
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Posted by admin on Jan 31, 2025 in |
Herbal therapy has been utilised for a very long time by ancient tribes and civilisations because it uses local herbs, which have less negative effects, to prevent and treat certain illnesses. The exotic plant Gliricidia sepium is a member of the Fabaceae family. Gliricidia’s generic name means “mouse killer” in Latin, referring to the usage of deadly seeds and bark as a rodenticide. In Gliricidia sepium, saponins, flavonoids, terpenes, tannins, glycosides, and volatile oils have been identified as important phytoconstituents from a variety of plant components, including leaves, flowers, fruits, stems, bark, seeds, and roots. Gliricidia sepium is said to possess antimicrobial and cytotoxic properties, thrombolytic activity, anti-bacterial activity, anti-inflammatory activity, anti-oxidant activity, wound healing, larvicidal activity, and anthelmintic activity, all of which are particularly significant in the medical sector. An overview of studies conducted on the plant Gliricidia sepium is presented in this article. It includes discussions on the taxonomy, classification, common names, vernacular names, description, distribution, phytochemicals, and pharmacological...
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Posted by admin on Jan 31, 2025 in |
To evaluate the Pharmacognostic properties, phytochemical screening, anthelmintic and anti-oxidant potential of the leaves of Euphorbia Hirta Linn. Microscopic and macroscopic characteristics of fresh and dried leaf samples were analysed. serial exhaustive extraction was done with various of solvents: Aqueous, Methanol, using Soxhlet apparatus. Physicochemical parameters such as moisture content, extractive values, ash content of leaf powder were also determined. The results revealed that the leaves extracts contain carbohydrates, alkaloids, steroids, Saponins, terpenoid, flavonoids etc., The results of anthelmintic study indicated that the methanolic and aqueous extracts significantly exhibited paralysis (P<0.01) in worms in lower doses (5, 10 and 15 mg/ml) and also caused death of worms especially at higher concentration of 15mg/ml, as compared to standard drug. These studies may be helpful for identification of Euphorbia Hirta Linn plant. This phytochemical may be responsible for the therapeutic activity of the plant. Further it useful for...
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Posted by admin on Jan 31, 2025 in |
GSTC is a polyherbal formulation comprising Commiphora mukul, Salacia reticulata, Terminalia arjuna, and Curcuma longa, developed to address atherosclerosis through multi-targeted mechanisms. Its phytochemical constituents include guggulsterones, mangiferin, arjunolic acid, and curcuminoids, each offering diverse pharmacological actions. Guggulsterones from C. mukul are recognized for their hypolipidemic and anti-inflammatory effects, while mangiferin and salacinol from S. reticulata provide antidiabetic, anti-obesity, and cholesterol-lowering benefits. T. arjuna contributes arjunolic acid and phytosterols, known for cardioprotective, antioxidant, and anti-inflammatory properties. Curcuminoids and ar-turmerone from C. longa exhibit potent antioxidant, anti-inflammatory, and hypolipidemic actions. Pharmacological studies demonstrate GSTC’s efficacy in reducing cholesterol, triglycerides, LDL, and VLDL levels while elevating HDL in high-fat diet models. Its mechanisms include inhibition of lipid peroxidation, regulation of HMG-CoA reductase, and modulation of inflammatory pathways such as NF-κB and COX-2. The formulation also prevents fatty liver accumulation and enhances lipid metabolism, GSTC exhibits significant antioxidant activity and platelet peroxidation inhibition. GSTC’s unique composition and pharmacological profile suggest its potential as a safe and effective therapeutic agent for managing atherosclerosis...
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