Posted by admin on Sep 30, 2026 in |
Urolithiasis is a common urinary tract disorder characterized by the formation and retention of urinary calculi, predominantly composed of calcium oxalate. The present study evaluated the anti-urolithiatic potential of Go-Pathri, an Ayurvedic marketed formulation, in experimental rats. Male Wistar albino rats were divided into five groups (n=6). Urolithiasis was induced using 0.75% ethylene glycol, followed by treatment with Cystone (750 mg/kg) or Go-Pathri (50 and 100 mg/kg) for 14 days. Urine volume, urinary calcium, oxalate, phosphorus and magnesium, and serum uric acid, creatinine and BUN were evaluated. Histopathological examination of renal tissues was also performed. Ethylene glycol produced marked alterations in urinary and serum biochemical parameters and promoted renal calcium oxalate deposition. Go-Pathri treatment improved urine output, reduced urinary stone-forming constituents and serum uric acid, creatinine and BUN levels, and reduced renal crystal deposition. The 100 mg/kg dose showed greater improvement than 50 mg/kg. These findings demonstrated the potential anti-urolithiatic and renoprotective effects of...
Read More
Posted by admin on Sep 30, 2026 in |
Background: Datura metel L. belongs to family Solanaceae is an annual or biennial shrub-like plant is native to Asia, Africa, and the Americas specifically to tropical and subtropical regions. The root of plant is used as analgesic, antipyretic, anti inflammatory, antispasmodic, wound healing, antifungal, antibacterial, sedative and hypnotic. Its significance increased due to its efficacy in case of bites of rabid dogs. Hence, Pharmacognostic evaluation of Datura metal L. dried Roots was carried out and reported. Methodology: Morphoanatomical, powder microscopic evaluation, physicochemical parameter TLC were carried out according to the API. Dried crude drug powder analysis, micro chemical evaluation, preliminary screening for phytoconstituent category were carried out as per standard protocol. Results: Diagnostic features of microscopic studies is characterized by presence of thick walled polygonal cork, lignified cells in cortical region, exarch xylem, lignified pitted parenchyma from xylem region and oil globules. Physicochemical parameter showed total ash (10.66%), acid insoluble ash (1.02%), water-soluble extractive (9.48%) and alcohol soluble extractive (2.46%). Conclusions: quality standard data for root of Datura metel...
Read More
Posted by admin on Sep 30, 2026 in |
Background: Iron deficiency anemia is a common nutritional disorder, and gastrointestinal adverse effects associated with conventional iron supplements may reduce adherence. Plant based gummies may provide a convenient dosage form, but their formulation characteristics require systematic evaluation. Objective: To develop and preliminarily evaluate a polyherbal nutraceutical gummy containing aqueous extracts of Moringa oleifera, Withania somnifera, Beta vulgaris, and Triphala. Methods: The plant materials were extracted separately with distilled water using ultrasonication. The extracts were evaluated for total ash, water-soluble extractive yield, qualitative phytochemical constituents, and iron content using the 1,10-phenanthroline UV–visible spectrophotometric method. Gummies prepared with agar and guar gum were assessed for weight variation, pH, moisture content, solubility, texture, non-specific UV diffusion at 278 nm, and preliminary stability. Results: Extractive yields were 15.02% for M. oleifera, 25.87% for W. somnifera, 20.05% for B. vulgaris, and 43.84% for Triphala. Their iron contents were 122.73, 24.44, 3.47, and 36.23 mg/100 g extract, respectively. The gummies had an average weight of 1.390 g, pH of 4.5, and moisture content of 18.85%....
Read More
Posted by admin on Sep 30, 2026 in |
Ranunculus sceleratus L. belongs to the family Ranunculaceae and is an annual herb widely distributed in moist habitats, including ditches, slow-moving streams and shallow ponds. The plant has a long history of use in traditional medicine, particularly in Asian traditional medical systems, where it has been employed for inflammatory disorders, skin conditions, rheumatic complaints, jaundice and other ailments. However, the fresh plant is toxic and contains irritant constituents associated with the ranunculin protoanemonin anemonin chemical system. Modern pharmacological investigations have provided evidence supporting several biological activities of R. sceleratus, including anti-inflammatory, hypotensive, antimicrobial, antifungal and hepatobiliary effects. Phytochemical investigations have identified flavonoids, phenolic acids, coumarisns, lignans, nitrogen-containing compounds, anthraquinones, sterols and lactone derivatives. A UHPLC-Q-Orbitrap HRMS investigation characterized 69 compounds in an 80% methanolic extract, substantially expanding the known chemical profile of the species. Experimental studies have demonstrated modulation of inflammatory mediators, inhibition of eicosanoid production, reduction of blood pressure and improvement of experimentally induced intrahepatic cholestasis. More recent phytochemical work has isolated previously undescribed benzopyran derivatives with inhibitory effects on...
Read More
Posted by admin on Oct 31, 2025 in |
Reproductive health and fertility can be shaped by a delicate balance of hormones, body functions, environment influences and lifestyle modifications. In recent years there’s been growing interest in role of nutraceuticals as these nutraceuticals consists of important vitamins, minerals, and antioxidants, nutritional foods that are crucial for improving reproductive health. Avocados, nuts, seeds, whole grains, green vegetables, fruits, and legumes are nutrient-rich foods that are known to promote hormonal balance, enhance the quality of eggs and sperm, and inhibit oxidative stress in reproductive organs. Particularly critical nutrients for enhancing ovulation, endometrial health, and sperm motility are folate, zinc, Tocopherols, iron, and omega-3 fatty acids. Additionally, diets high in antioxidants protects gametes from damage caused by free radicals, augmenting the probability of conception. A balanced lifestyle and adequate consumption of these fertility-promoting foods can help control infertility and greatly enhance reproductive results. Nutritious diets are therefore a safe, all-natural, and successful therapeutic strategy for treating...
Read More
