Posted by admin on Dec 11, 2015 in |
Herbals are playing a major role in Siddha system of medicine. Herbals contain plant materials as their pharmacologically active components. The aim of the study is to evaluate the acute and sub-acute toxicity of the Siddha herbal preparation Lagu Seena Chooranam (LSC) for the treatment of Scabies in the pediatric age group. For acute studies, different doses of LSC were administered orally to rats once daily for one week. For sub-acute studies, different doses were administered orally to rats once daily for 28 days in various doses at 200, 400 mg/kg of body weight. Detailed hematological, biochemical, necropsy and histopathological evaluation of organs were performed for all animals. Histopathological analysis revealed that spleen, testes, pancreas, lung, liver, brain, heart, stomach, intestine, bone, ovary, and kidney tissues of treated groups did not show any signs of toxicity. No destruction in hepatic, renal, hemopoietic functions was observed throughout the...
Read More
Posted by admin on Dec 11, 2015 in |
Kameela or Kamala is a well known Unani drug which is being used as medicament from centuries for the treatment of Amraze Jildiya (skin disease) by Unani Physicians and also mentioned their medicinal efficacy in Unani classical text. It is widely scattered perennial shrub or small tree in tropical and subtropical region regions with an altitude below the 1,000 m and is a description to have a broad range of pharmacological activities. There are many chemical constituents documented such as phenols, steroids diterpenoids, triterpenoids, flavonoids, coumarins, isocoumarins, cardenolides and particularly phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported different biological activities such as antimicrobial, cytotoxicity, antifungal, antiviral, antioxidant, anti-inflammatory. Roghan Kameela and Zimad Jarb are well established compound drug of Unani system for the treatment of Jarb (Scabies) and Kharish (itching) which is time tested and safe. The present review reveals that Mallotus philippinensis is a precious source of natural medicament and provides persuasive support for its potential use in a modern...
Read More
Posted by admin on Dec 11, 2015 in |
Elimination and Eradication is an important component of the Global Strategy for combating malaria, and one of the ways of achieving this purpose is blocking the transmission of malaria parasites from humans to mosquito vectors. The ability of Plasmodium to cease asexual replication in the erythrocytes of the human host and commit to the formation of gametes necessary for sexual replication in the gut of the mosquito vector is essential for efficient transmission of malaria. Although a conserved member of the Apicomplexan AP2 family of transcriptional factors acts as the master switch in triggering the transcriptional cascade that initiates gametocytogenesis, some environmental factors including some antimalarial drug treatments, are believed to switch on the gene(s) that determine the commitment to the sexual phase. Antimalarial agents have different effects on gametocyte carriage depending on their mechanisms of action. This review enumerates the role of various classes of antimalarial agents in either promoting or preventing plasmodium gametocytogenesis and points out the need to, in addition to exiting gametocytocidal, design new drugs...
Read More
Posted by admin on Oct 1, 2014 in |
Rheumatoid arthritis is a chronic immuno-inflammatory systemic disease, affecting 1-2% population worldwide. The disease is very common among women rather men. Mostly the victims of this disease belong to the age group 45 onwards, while juvenile cases are also reported. The exact pathogenesis of the disease is still a question. Reactive oxygen species have been implicated as mediators of tissue damage in arthritic patients. Various herbal plant preparations are reported to scavenge free radicals and improve different human diseases such as diabetes, Alzheimer’s disease, atherosclerosis, etc. The present investigation was designed to evaluate the effectiveness of Nyctanthes arbortristis towards disturbed antioxidant status in inflamed tissue. Nyctanthes arbortristis has been known for medicinal uses such as anti-helmenthic, anti-bacterial activity, etc. Water-soluble ethanolic extract of Nyctanthes seed (NSE) and leaf (NLE) was administered orally to adjuvant-induced arthritic mice (AIA) at the dose of 23.72 mg/kg body weight for 47 days. Enzymatic and non-enzymatic anti-oxidants were assessed on day 2, 14 and 47. On the one hand, daily administration of NLE significantly...
Read More
Posted by admin on Oct 1, 2014 in |
Introduction: Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type-II. Different factors increase insulin resistance, but FFA is the most common factor to increase insulin resistance. Aims and Objectives: Most of the obese person (80%) is DM Type-II, but all obese are not diabetic, why? To study the FFA level in obese without DM Type-II verses obese with DM Type-II subjects. Materials and Methods: Subjects were taken from OPD & IPD, Department of Medicine, SRMS, IMS Bareilly (U.P.) India, of both sexes, coming from reasonable distances around Bareilly city. They were from the lower and middle class of rural area having moderate physical activities, with vegetarian as well as non-vegetarian dietary habits and were obese as per new Asian BMI guidelines and have symptoms of diabetes. Subjects were not on any drug treatment before taken blood sample. Serum FFA level estimated by ELISA...
Read More
