Posted by admin on Jan 30, 2016 in |
Aim of the present study is to analyze Mūcāmparap paṛṛu, a poly herbomineral Siddha formulation for physicochemical parameters, TLC photo documentation, and HPTLC fingerprint profile studies. The physicochemical parameters such as ash contents, solubility in water and ethanol, pH, loss on drying and successive extraction with hexane, chloroform, and ethanol were carried out. Hexane, chloroform, and ethanol extracts were subjected to TLC photo documentation, HPTLC analysis. HPTLC fingerprint profile under UV 254 nm, hexane extract showed 13 peaks, chloroform showed 9 peaks and ethanol showed 10 peaks; under UV 366 nm, hexane showed 11 peaks, chloroform showed 15 peaks and ethanol showed 12 peaks; after derivatization with vanillin-sulphuric acid all the extracts showed 11 peaks. The results obtained in the study are specific and could be used as a reference in the quality control of the...
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Posted by admin on Jan 30, 2016 in |
New series of N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl) 2-methyl-1H-indole-3-carboxamide derivatives (VIa-d) were prepared and tested for their antibacterial and antifungal activity. The synthesis is based on the condensation of phenylhydrazine and ethyl acetoacetate in the presence of acetic acid to ethyl (2-methyl-1H- indol-3-yl)-2-oxoacetate (III) which on reaction with hydrazine hydrate gives 2-(2-methyl-1H-indol-3-yl)-2-oxoacetohydrazide (IV). Further conden-sation of oxoacetohydrazide and substituted benzaldehyde gave carbohydrazide derivatives (Va-d). Finally addition of triethylamine in dry 1, 4-dioxane and chloroacetyl chloride gave N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl)2-methyl-1H-indole-3-carboxamide derivatives (VIa-d). The structure of newly synthesized 4-Oxoazetidin Substituted derivatives has been established by spectral (IR, 1HNMR) data. These compounds were screened for antibacterial and antifungal activity against various gram-positive and gram-negative strains. All the compounds show significant antibacterial and antifungal...
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Posted by admin on Jan 30, 2016 in |
Acute and chronic inflammation is the most important issue in the field of health. Also, due to the side effects of synthetic drugs, herbal products are widely used in the control of inflammation. In this study was investigated the effect of a hydro-alcoholic extract of Japanese persimmon fruit on the formalin-induced inflammation in the rat paw. 30 male Wistar rats were divided into 5 groups: negative control, group treatment with 300 mg/kg of aspirin (positive control group) and the group’s treated with 200, 400 and 800 mg/kg hydro-alcoholic extract of persimmon, respectively. The inflammation was established to sub-planter injection of 2.5% formalin in rats. Level of inflammation was measured to plethysmometer in six stages in the rat paw. These results were shown that in the rat’s treated with different concentrations of extract; inflammation was lower than the positive control group (p≤0.05). Also, the compression of between groups’ treatment with the extract was determined that reduction of inflammation was as dose depend manner (p≤0.05). We conclude that Japanese persimmon may...
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Posted by admin on Jan 30, 2016 in |
Cardiac diseases are responsible for more number of deaths in India and the rest of the world. There are various synthetic drugs which are being used for cardiac diseases. The limitation of synthetic drugs is most of them shows anarchic side effects to human systems. Medicinal plants are gaining a lot of importance nowadays because of efficacy they have been showing in the traditional healing. Plants are the exemplary source of inhibitors for various diseases. In this short review an attempt has been made to review the Medicinal plants which have potent cardioprotective activity that is present in the west godavari district of Andhra Pradesh, India such as Daucus carota, Hibiscus rosa sinensis, Bacopa monneira, Moringa oleifera, etc., of about 10 plants were reviewed and their photographs have also been included in this...
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Posted by admin on Jan 30, 2016 in |
Plants have been the basis of many traditional medicines throughout the world for thousands of years and have continued to provide new remedies to mankind. They are one of the most abundant sources of bioactive compounds. The genus Passiflora L. comprises about 520 species of dicotyledonous plants in the family Passifloraceae. Passiflora incarnata and P. alata, also commonly known as passion flower, are two species of a perennial climbing vine with beautiful exotic flowers and delicious fruit that grow worldwide, preferring subtropical, frost-free climates. They are native to the tropical and semi-tropical United States (Virginia to Florida and as far west as Texas), Mexico, Central American, and from Brazil to Paraguay through northern Argentina. It is used extensively for the treatment of some diseases like anxiety, insomnia, convulsion, sexual dysfunction, cough, and cancer. Passionflower is currently official in the national Pharmacopeia’s of Egypt, France, Germany, and Switzerland, and also monographed in the British Herbal Pharmacopoeia and the British Herbal Compendium, the ESCOP monographs, the Commission E, the German Standard...
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