FORMULATION, DEVELOPMENT AND STANDARDIZATION OF AN AYURVEDIC MUCO-ADHESIVE EXTENDED RELEASE VAGINAL TABLETAbstract
The study aims to standardize a vaginal herbal formulation consisting of stem barks of Ficus glomerata Roxb. and Symplocos racemosa Roxb. Since they are used as Ayurvedic medicine and described in ancient text Charak Samhita as astringent, anti-inflammatory and treatment of vaginitis/leucorrhoea. This new herbal formulation is likely to exhibit significant antimicrobial action due to the presence of phenolic and flavonoid compounds. The extractive value was 1.64 and 1.70% w/w for aqueous and alcoholic extract. Total Phenol Content was 225.67 and 220.00 µg Gallic acid equivalent/mg for aqueous and alcoholic extract. Fifteen types of mucoadhesive tablets weighing 550, 700 or 900 mg each were prepared using combinations of research drug, Carbopol and Hydroxy-Propyl-Methyl Cellulose as polymers, talc as a glidant, magnesium stearate as a lubricant and Micro-Crystalline Cellulose and Lactose monohydrate as diluents. Similarly, five types of effervescent mucoadhesive tablets using sodium bicarbonate and citric acid in 3:1 ratio were prepared. Apart from weight, thickness, hardness, and friability of each group, the surface pH, swelling index and muco-adhesive force were determined. The formulation F-XII provides best physical parameters of hardness (6.0 ± 2.53 kg/sq.cm), pH value (4.80 ± 0.04), swelling index (69.39 ± 0.44% w/w) and muco-adhesive force (0.667 ± 0.02 Newton) which indicate its sustained slow releasing of anti-vaginitis drug delivery as an effective mucoadhesive vaginal tablet.
M. Gupta *, S. Kumar, B. B. Bhowmik, N. Karmakar and S. Sasmal
Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, West Bengal, India.
11 May 2017
21 August 2017
17 September 2017
01 January 2018