Posted by admin on Jan 28, 2017 in |
Hyperlipidemia is the most prominent risk factor in coronary heart disease. The present study was designed to investigate the anti-hyperlipidemic activity of Amorphophallus paeoniifolius Tuber in Triton WR-1339 induced hyperlipidemic rats. Amorphophallus paeoniifolius extract was administered at a different dose of 250mg/kg, 500mg/kg (p.o) daily for 7 days to hyperlipidemic rats. Gemfibrozil is used as a reference standard. The statistical analysis was performed by using one way ANOVA followed by the Dunnet’s multiple comparison tests. This is to highlight the presence of the different secondary metabolites, extract by solvents (ethanol) and analyze the content of total phenols from the tuber by the visible UV spectrophotometry method. The results obtained indicate that the tuber of Amorphophallus paeoniifolius contains high concentrations of total phenols (respectively 79, 35 mg GAE/gDM). These polyphenols possess a strong anti-hyperlipidemic activity. Amorphophallus paeoniifolius showed a significant decrease in the levels of serum cholesterol, triglycerides, LDL (low-density lipoprotein), VLDL (very low-density lipoprotein) and the significant increase in the level of serum HDL (high-density lipoprotein) at the dose...
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Posted by admin on Jan 28, 2017 in |
Extracts from leaves, stems and flower buds of Myrciaria glazioviana were analyzed for their antioxidant and anticholinesterase activity. The methanolic extracts showed the best results in reducing power (623.52 – 806.15 mg AA/g of extract), DPPH radical scavenging (IC50 = 9.77 – 14.06 µg/mL) and lipid peroxidation inhibition activity (21.30 – 66.80%). These data were correlated to the total phenolic content (270.19 – 351.01 mg GA/g of extract). The dichloromethane extract of leaves exhibited a higher anti-cholinesterase potential (IC50 = 249.25 µg/mL). Furthermore, the chemical composition of the essential oils from leaves collected in all seasons of the year was analyzed by GC-MS and GC-FID. Only sesquiterpenes were identified in all essential oils, and non-functionalized sesquiterpenes comprised the major fractions (from 66.8 to 79.3%). An increase in non-functionalized compounds was observed in the warmer seasons. Germacrene B was the major compound in all seasons (from 26.8 to 30.1%). In winter and autumn, high contents of germacrene D (10.2 and 10.0%, respectively) and α-cadinol (12.1 and 12.0%, respectively) were identified;...
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Posted by admin on Jan 28, 2017 in |
Thepesia populnea Linn. (Family- Malvaceae) is one of the important drugs used in Herbal medicines. It is known by the name Paras-pipal. It is often cultivated for ornament and shade, and it blooms throughout the year in the tropics. Various parts of this plant are found to possess useful medicinal properties, such as antifertility, antibacterial, anti-inflammatory, antioxidant, purgative, and hepatoprotective activities. The yellow juice of fruits is employed in treating certain hepatic diseases. A decoction of the bark is given internally in the diseases of the skin and that of the fruits as an antidote for poisoning. The seed possesses purgative properties. The plant is useful in malaria. A wide range of biologically active compounds such as flavonoids, sesquiterpenoids, tannin, saponins, alkanes, essential oil, sugars, fatty acids, and antioxidants are present in the plant. This contribution provides a comprehensive review of its ethnomedicinal uses, chemical constituents and pharmacological profile as a medicinal...
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Posted by admin on Jan 30, 2016 in |
The global market for herbal products is exploding. The major hindrance in the amalgamation of herbal medicines into modern medical practices is the lack of scientific and clinical data and a better understanding of efficacy and safety of the herbal products. The evaluation or standardization of a crude drug involves Pharmacognostic methods such as organological, physicochemical, phytochemical and pharmacological analysis. The experimental material selected for the present study is Tragia plukenetii R. Smith belongs to the family Euphorbiaceae. This herb is distributed in hill slopes of southern peninsular India. The root is diaphoretic and alternative and is given for fevers to cause perspiration. The present paper deals with anatomical characters of leaf, stem, and roots. The dried powders of stem, leaves and roots and their extracts in various solvents were examined with ordinary light and U.V. light (365nm). Quantitative determination such as moisture content, total ash, water-soluble ash, acid insoluble ash, water extractive values, and sulfated ash have also been made. Preliminary phytochemical analysis of the extracts was done...
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Posted by admin on Jan 30, 2016 in |
The plant of Desmodium triflorum Linn (Fabaceae) is reported to have great medicinal value. The aim of this study to evaluate pharmacognostic evaluation including examination of morphological characters, ash value, powder analysis, and extractive values was carried out. Phytochemical screening including chemical examination and chromatographic study were also carried out. This would help to scientifically justify its pharmacological activities of particular chemical constituents in different...
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