Posted by admin on Jul 1, 2014 in |
Traditional herbal medicines include herbs, herbal materials, herbal preparations and finished herbal products that contain active ingredients parts of plants, or other plant materials, or combinations. Clinical trials of traditional herbal medicines are carried out with herbal preparations only after standardization and identification of markers to ensure that the substances being evaluated are always the same. It is very important to assess the direct and indirect risks associated with traditional herbal medicines. This can only be established once the safety and efficacy of herbal medicines are being proven during clinical trials. There are various concerns over the clinical trial designs in India. It has been observed that during clinical trials various problems are being observed such as Batch to batch variation, use of placebo instead of innovative product, inadequate quality control system, the inadequate requirement for the assessment of safety and efficacy for different types of herbal medicines and difficulty in quantification due to complex nature of extract. This review focuses on the current status of clinical trials of...
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Posted by admin on Jun 1, 2014 in |
Infinite varieties of plants- both medicinal and aromatic are seen on the Indian continent. Siddha system of medicine is effectively making use of them. Sage Yugi have classified skin diseases into 18 kuttas. Pundareega kuttam is one among them. It can be correlated to dermatophytosis in modern science. Siddhars, scientists of a sort have found a remedy to the newly emerging mysterious diseases during their lifetime in the remote past. A thorough literature survey brings them to the limelight. Medicinal plants with antimicrobial activity are found widely in Siddha literature. Many effective compound formulations are also available to treat dermatophytosis. This article focuses on the herbs having in-vitro anti- dermatophytic activity and medicinal plants in Siddha literature for treating dermatophytosis. This preliminary literature search will help to understand the potential for further research in this...
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Posted by admin on Jun 1, 2014 in |
Stem cell biology, many signals regulated stem cells and organ development. Wnt factors play a crucial role in stem cells development and induced signaling pathway in stem cells. Wnt signals classified as a canonical and non-canonical pathway. Wnt factors regulated both pathways for stem cells self-renewal, proliferation, and differentiation. Wnt canonical pathway induced by Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt10a and Wnt10b. Wnt non-canonical pathway regulated by Wnt factors such as Wnt1, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, Wnt9a, Wnt9b, Wnt10a, Wnt10b, Wnt11, and Wnt16. These all factors have a specialized role in stem cells and development. These factors also regulated wound healing mechanism and variety of organ regeneration. Finally, abnormality or aberrant expression of Wnt signals regulated a variety of...
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Posted by admin on Jun 1, 2014 in |
Diabetes mellitus (DM), both insulin-dependent DM (IDDM) and non-insulin dependent DM (NIDDM) is a common and serious metabolic disorder throughout the world. Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Among many medications and other alternative medicines, several herbs have been known to cure and control diabetes; additionally, they have no side effects. The present paper is an attempt to list the plants with anti-diabetic and related beneficial effects originating from different parts of the world. History showed that medicinal plants had been used in traditional healing around the world for a long time to treat diabetes; this is because such herbal plants have hypoglycemic properties and other beneficial properties, as reported in scientific literature. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat diabetes mellitus, describes that the anti-diabetic activity of medicinal plants is due to the presence of phenolic compounds, flavonoids, terpenoids, coumarins and other constituents which...
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Posted by admin on May 1, 2014 in |
High blood pressure is well-established as a leading cause of stroke, ischemic heart disease, and cardiovascular disease. Globally cardiovascular disease accounts for approximately 17 million deaths a year, nearly one third of the total. A number of pharmaceutical agents are available for initial treatment of high BP. These include older molecules such as diuretics and beta-blocking agents, and newer molecules such as dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and direct acting vasodilators. Comprehensive hypertension management focuses on reducing overall cardiovascular risk and should be the preferred approach for initial management of hypertension. Nitric oxide is a gaseous signaling molecule that regulates various physiological and pathophysiological responses in the human body. Nitric oxide is a gaseous lipophilic free radical which reacts with various molecules to cause pleiotropic effects and it is generated by three distinct isoforms of nitric oxide synthase. The physiologic effects include circulation and blood pressure, platelet function, host defense, and neurotransmission in central nervous system and in peripheral nerves. The etiology of the...
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