SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVESAbstract
2-Amino-1-aryl-1, 4, 5, 6, 7, 8-hexahydro-4-phenyl-quinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidine-malononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. Also, the antimicrobial activity of the newly synthesized derivatives was reported.
S. M. Sherif * and H. R. M. Rashdan
Department of Chemistry, Faculty of Science, Ain-Shams University, Cairo, Egypt.
20 June 2014
27 December 2014
30 December 2014
01 January 2015