SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES
Abstract2-Amino-1-aryl-1, 4, 5, 6, 7, 8-hexahydro-4-phenyl-quinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidine-malononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. Also, the antimicrobial activity of the newly synthesized derivatives was reported.
Article Information
4
21-27
671
1388
English
Ijp
S. M. Sherif * and H. R. M. Rashdan
Department of Chemistry, Faculty of Science, Ain-Shams University, Cairo, Egypt.
hudadawoud20@yahoo.com
20 June 2014
27 December 2014
30 December 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.IJP.2(1).21-27
01 January 2015