ROLE OF PLANT-BASED ACTIVE COMPOUNDS IN INFLAMMATORY RESPONSES OF CANCERAbstract
Cancer is a non-communicable life-threatening disease and a majority of cancers are caused due to inflammatory responses and association with precursor lesions termed as proliferative inflammatory factors. Inflammatory response arises because of dysfunction of anti-oxidative proteins due to DNA damage and may increase oxidative stress. This review mainly focuses on the inflammatory factors which trigger specific pathways inside the cell and create a tumour microenvironment that subsequently leads to cancer induction and progression. We are providing information about the role of various plant derived active compound and their role in treatment of cancer via induction of chronic inflammation and altering the level of reactive oxygen species (ROS). In this review, we will also document currently available treatments and their possible therapeutic implications in ameliorating the ailments that arise due to cancer. In the later section of this review, we have added notes on the challenges that need to be addressed to improve the efficiency of drugs derived from medicinal plants. It appears that herbal therapies are effective for targeting the cellular compartment and effectively correcting the tumour microenvironment and plays a major role inmodulating the inflammatory responses.