PREPARATION AND EVALUATION OF ANTI-ACNE PHARMACEUTICAL GEL CONTAINING HENNA AND CHAMOMILE EXTRACTSAbstract
Acne is a skin-related condition entailing many psychological complications. Although several medications have been developed, natural remedies attracted more attention because of the less side effects and multifunctional. The objective of this study was to prepare and evaluate the anti-acne effects of a pharmaceutical gel containing herbal extracts, including Lawsonia inermis and Matricaria chamomilla. The total phenolics of extracts were determined with the Folin-Ciocalteu method. Using Hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC) and propylene glycol (PEG), the pharmaceutical gel was formulated and the physical properties of the formulation were specified at 37 ± 2 °C. The release of the active ingredients from the optimum formulation was investigated using Franz cell device. The results showed that the optimum formulation was stable at least for 3 months. The total phenol content of the aqueous extract of Henna leaves, hydroalcoholic extract of chamomile flowers, and the optimum formulation was 57.8 mg/g ex, 181.08 mg/g and 202.75 mg/g, respectively. Nearly 80 % of the phenolic compounds in the optimum formulation were released over 4 h. The phenolic compounds have inhibitory effects on the growth of S. aureus and P. aeruginosa. It was concluded that the formulation exhibits excellent stability, viscosity, homogeneity, greater extrudability, and enhanced antibacterial activity, which can be employed as a local pharmaceutical gel in acne treatment.
M. Bagheria, Y. Shokoohiniab, Z. Pourmanouchehrib, S. Khaledianc, F. Jalilianb, S. Mirzaieb and L. Behboodb *
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
21 April 2020
24 July 2020
28 July 2020
01 August 2020