NEUROCHEMICAL SCREENING OF PTEROSPERMUM ACERIFOLIUM IN ANIMAL MODELSAbstract
Pterospermum acerifolium is a common to plant in India is considered carminative, stimulant and emmenagogue. In the present study, the ethanol extract of the bark of Pterospermum acerifolium has been evaluated for Neurochemical study. Treatment with ethanolic extract of Pterospermum acerifolium was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and -endorphin (-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ethanolic extract of Pterospermum acerifolium was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT). The results obtained from this study suggested that the memory-enhancing effect of ethanolic extract of Pterospermum acerifolium was mediated through regulations of neurochemical and neuroendocrine systems. From the present study, it was concluded that herbal drugs could be potentially used to control the state of CNS disorders. Further investigations are, however, necessary to explore mechanism(s) of action involved in these pharmacological activities.
A. Choubey * and G. Garg
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.
01 October 2014
21 October 2014
24 December 2014
01 January 2015