MEMBRANE STABILIZATION, INHIBITION OF ‘HISTAMINE AND PROSTAGLANDIN SYNTHESIS’ MEDIATED ANTI INFLAMMATORY RESPONSE OF SOME INDIGENOUS PLANTS

In the present study the anti-inflammatory, analgesic activity and mechanistic pathway of Centratherum anthelminticum (Willd.) Kuntze (CA), Cissus quadrangularis Linn. (CQ) and Kigelia pinnata DC (KP) was tested in rats using carrageenan induced paw edema method. The central analgesic activity was assessed by radiant heat method, hot plate method, and tail immersion method. The peripheral analgesic action was estimated using acetic acid induced writhing test. To establish the mechanism of action of the hydroalcoholic extract, membrane stabilization, antioxidant, antihistaminic, muscle strength, and coordination activity were performed. In anti-inflammatory activity; CA, CQ, and KP showed maximum inhibition of 77%, 70% and 50% respectively. In analgesic activity, CA and CQ treated animals responded propitiously to both central and peripheral analgesia, but KP treated animals demonstrated significant activity only for peripheral analgesia. This can be attributed to membrane stabilization, anti-oxidant, and antihistaminic potential. All the three test drugs have shown both anti-inflammatory activity and analgesic activity with varying potency and mechanisms of action.