JORDANIAN MEDICINAL PLANTS AS AN ALTERNATIVE SOURCE FOR NEW ANTIMICROBIALS AGAINST MULTI DRUG RESISTANT: REVIEWAbstract
Antibiotic resistance is one of the biggest threats to global health, food security, and development today. Medicinal plants have historically proven their value as a source of molecules with therapeutic potential. The interest in natural product-based drug discovery has revitalized in recent years because synthetic compound libraries and high throughput screening for discovery of new drug leads did not meet the expectations. The aim of this study is to systematically review the use of Jordanian medicinal plants then identify the most attractive plant for the discovery and development of drugs against resistance Staphylococcus aureus and Pseudomonas aeruginosa based on data collected from previous studies, that investigate the inhibitory effects of methanolic extracts of 8 Jordanian plants and their combinations with three antibiotics, on resistance of Staphylococcus aureus and Pseudomonas aeruginosa and studies that collected information from local population concerning the use of medicinal plants in Jordan. The results suggested that Artemisia herba-alba used in Jordan as traditional medicine has been reported to have a significant effect against the resistance of Staphylococcus aureus and Pseudomonas aeruginosa when combined with chloramphenicol, gentamycin, and cephalexin. Artemisia herba-alba that may help in the discovering of a new antibiotic.
A. M. J. Al-Samydai
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan.
09 June 2018
05 July 2018
09 July 2018
01 September 2018